The five-year multi-centre research project ������Ƶ� supported by ������Ƶ10mn funding from Wellcome ������Ƶ� involves researchers from the Universities of Cambridge, Kent, Manchester, Oxford, and Imperial College London. SynHG is led by Professor Jason Chin of the MRC Laboratory of Molecular Biology; he was also recently announced as the founding Director of the Generative Biology Institute at the Ellison Institute of Technology, Oxford, and a Professor at the University of Oxford.

A dedicated social science programme, led by Professor Joy Zhang of the Centre for Global Science and Epistemic Justice at the University of Kent, runs throughout the project alongside the scientific development. The programme will work with civil society partners around the world to actively explore, assess and respond to the socio-ethical implications of tools and technologies developed by SynHG.

The benefits of human genome synthesis to research and beyond 
Since the completion of the Human Genome Project at the start of the century, researchers have sought the ability to write our genome from scratch. Unlike genome editing, genome synthesis allows for changes at a greater scale and density, with more accuracy and efficiency, and will lead to the determination of causal relationships between the organisation of the human genome and how our body functions. Synthetic genomes have the potential to open up brand new areas of research in creating targeted cell-based therapies, virus-resistant tissue transplantation and extensions may even enable the engineering of plant species with new properties, including the ability to withstand harsh climate. 

To date, scientists have successfully developed synthetic genomes for microbes such as E. coli. The field of synthetic genomics has accelerated in recent times, and advances in machine learning, data science and AI showing promise, with synthesised DNA becoming more widely available. However, today������Ƶ�s technology is not able to produce large, more complex sections of genetic material, such as found in crops, animals and humans. 

The research team are focusing on developing the tools and technology to synthesise large genomes exemplified by the human genome. Focusing on the human genome, as opposed to other model organisms such as mice, will allow researchers to more quickly make transformative discoveries in human biology and health.

 Professor Jason Chin, Founding Director of the Generative Biology Institute at EIT, Oxford, said: ������Ƶ�The ability to synthesize large genomes, including genomes for human cells, may transform our understanding of genome biology and profoundly alter the horizons of biotechnology and medicine. With SynHG we are building the tools to make large genome synthesis a reality, and at the same time we are pro-actively engaging in the social, ethical, economic and policy questions that may arise as the tools and technologies advance.  We hope that Wellcome������Ƶ�s support for this combination of approaches will help facilitate substantive societal benefit.������Ƶ�

A bold, ambitious project facing complex scientific challenges 
SynHG focuses on developing the foundational tools and methods required to equip more researchers in the future. This research journey will potentially catalyse new technologies in the field of engineering biology, generating exciting discoveries about how cells use their genomes even before achieving complete genome synthesis. 

The team of researchers hope to provide proof of concept for large genome synthesis by creating a fully synthetic human chromosome, which makes up approximately 2% of our total DNA. Initially, the team hope to establish methods where small changes are made to the sequence of a chromosome with minimal onward effect on the proteins that it produces. 

Setting the foundation ������Ƶ� testing the concept, iterating the methods, and embedding ethical considerations ������Ƶ� could alone take many years. Even as engineering biology technologies improve, reliably building a complete synthetic human genome and meaningfully applying it to human health will likely take decades.

Michael Dunn, Director of Discovery Research at Wellcome, said: ������Ƶ�Our DNA determines who we are and how our bodies work and with recent technological advances, the SynHG project is at the forefront of one of the most exciting areas of scientific research. Through creating the necessary tools and methods to synthesise a human genome we will answer questions about our health and disease that we cannot even anticipate yet, in turn transforming our understanding of life and wellbeing.������Ƶ� 

Professor Patrick Yizhi Cai, Chair of Synthetic Genomics at the University of Manchester said: "We are leveraging cutting-edge generative AI and advanced robotic assembly technologies to revolutionize synthetic mammalian chromosome engineering. Our innovative approach aims to develop transformative solutions for the pressing societal challenges of our time, creating a more sustainable and healthier future for all."

Embedding global socio-ethical discussions in scientific advancements 
To effectively translate scientific ambition into meaningful and potentially profound societal benefits, it is essential that there is proactive and sustained engagement with the evolving socio-ethical priorities and concerns of diverse communities. 

Wellcome is also funding Care-full Synthesis, a dedicated social research initiative conducting empirical studies with diverse publics worldwide. Led by Professor Joy Y. Zhang and hosted by the Centre for Global Science and Epistemic Justice (GSEJ) at the University of Kent, the project builds on GSEJ������Ƶ�s global network of academic, civil society, industry and policy partners to promote a new approach of science������Ƶ�society dialogue that is Open, Deliberative, Enabling, Sensible & Sensitive, and Innovative (������Ƶ�ODESSI������Ƶ�). 

Professor Joy Zhang, Founding Director of the GSEJ at the University of Kent said: ������Ƶ�With Care-full Synthesis, through empirical studies across Europe, Asia-Pacific, Africa, and the Americas, we aim to establish a new paradigm for accountable scientific and innovative practices in the global age������Ƶ�one that explores the full potential of synthesising technical possibilities and diverse socio-ethical perspectives with care.������Ƶ� 

Over the next five years, the team will undertake a transdisciplinary and transcultural investigation into the socio-ethical, economic, and policy implications of synthesising human genomes. The project places particular emphasis on fostering inclusivity within and across nation-states, while engaging emerging public������Ƶ�private partnerships and new interest groups. 

Through the generation of rich empirical data, the team will develop a toolkit to enable effective integration of careful thinking into the management, communication, and delivery of human genome synthesis. This work aims to substantially expand the practice of accountable science and innovation, reflecting the complex realities of a hyperconnected yet ideologically fragmented world. Care-full Synthesis will achieve this by advancing a fresh approach to engaging with global communities, ensuring that fast-moving science is accompanied by robust social and legal deliberation, and identifying innovative strategies to co-ordinate regional and global governance accounting for diverse social priorities and scientific pathways.

Designed by the undergraduate Physics Society, the sculpture is based on the telescope������Ƶ�s original engineering blueprints, ensuring a high level of accuracy and detail. Student James Ruxton spent six months perfecting the design using computer software to model and test different structures, producing a 4,000-page instruction manual. He even custom-designed some Lego pieces, using a 3D printer to create bespoke bricks. 

James and fellow Physics Society members began building the sculpture in late April. The finished model weighs 30kg, with 12.5kg attributed to the dish alone. Due to its weight, the dish had to be reinforced with a steel pole������Ƶ�mirroring a real-life engineering challenge faced during the telescope������Ƶ�s original construction eighty years ago. 

The sculpture serves as a tribute to the University������Ƶ�s pioneering role in astrophysics and engineering. It will be on permanent display in the Schuster Building, housed in a specially modified cabinet alongside a Lego model of a Large Hadron Collider detector������Ƶ�built by students a decade ago. 

A unique feature of the sculpture is a brick which was signed by Dame Jocelyn Bell Burnell - the physicist who discovered Pulsars - during her visit to the University to deliver this year������Ƶ�s annual Bragg Lecture in March.  

The sculpture arrives in time to commemorate the 80th anniversary of Jodrell Bank, a site of immense significance to The University of Manchester and to science in the UK.  

Professor Chris Parkes, Head of the Physics and Astronomy department, has been supporting the students with their project. He reflected: ������Ƶ�Jodrell Bank has always been a symbol of bold innovation - pushing the boundaries of science and engineering from its earliest days.  

In December 1945, physicist Bernard Lovell travelled from Manchester to a quiet field in Cheshire hoping to explore the use of radar in cosmic ray detection. Instead, this became the start of the Physics Department's world-famous Jodrell Bank radio astronomy observatory.  

Over the following 12 years, Lovell and his team constructed the telescope that now bears his name. Its global importance was confirmed in 1957 when it became the only instrument capable of tracking the rocket carrying Sputnik 1, launched by the Soviet Union during the Space Race.  

Since then, the Lovell Telescope has stood at the forefront of astronomical research. In 2019, the Jodrell Bank Observatory was granted UNESCO World Heritage status, further cementing its legacy as a beacon of scientific innovation. 

In a boon for the future of data storage technologies, the researchers have made a new single-molecule magnet that retains its magnetic memory up to 100 Kelvin (-173 °C) ������Ƶ� around the temperature of the Moon at night.

The finding, published in the journal , is a significant advance on the previous record of 80 Kelvin (-193 °C). While still a long way from working in a standard freezer, or at room temperature, data storage at 100 Kelvin could be feasible in huge data centres, such as those used by Google.

If perfected, these single-molecule magnets could pack vast amounts of information into incredibly small spaces ������Ƶ� possibly more than three terabytes of data per square centimetre. That������Ƶ�s around half a million TikTok videos squeezed into a hard drive that������Ƶ�s the size of a postage stamp.

The research was led by The University of Manchester, with computational modelling led by the Australian National University (ANU).

David Mills, Professor of Inorganic Chemistry at The University of Manchester, said: ������Ƶ�This research showcases the power of chemists to deliberately design and build molecules with targeted properties. The results are an exciting prospect for the use of single-molecule magnets in data storage media that is 100 times more dense than the absolute limit of current technologies.

������Ƶ�Although the new magnet still needs cooling far below room temperature, it is now well above the temperature of liquid nitrogen (77 Kelvin), which is a readily available coolant. So, while we won������Ƶ�t be seeing this type of data storage in our mobile phones for a while, it does make storing information in huge data centres more feasible.������Ƶ�

Magnetic materials have long played an important role in data storage technologies. Currently, hard drives store data by magnetising tiny regions made up of many atoms all working together to retain memory. Single-molecule magnets can store information individually and don������Ƶ�t need help from any neighbouring atoms to retain their memory, offering the potential for incredibly high data density. But, until now, the challenge has always been the incredibly cold temperatures needed in order for them to function.

The key to the new magnets������Ƶ� success is its unique structure, with the element dysprosium located between two nitrogen atoms. These three atoms are arranged almost in a straight line ������Ƶ� a configuration predicted to boost magnetic performance but realised now for the first time.

Usually, when dysprosium is bonded to only two nitrogen atoms it tends to form molecules with more bent or irregular shapes. In the new molecule, the researchers added a chemical group called an alkene that acts like a molecular pin, binding to dysprosium to hold the structure in place.

The team at the Australian National University developed a new theoretical model to simulate the molecule������Ƶ�s magnetic behaviour to allow them to explain why this particular molecular magnet performs so well compared to previous designs.

Now, the researchers will use these results as a blueprint to guide the design of even better molecular magnets.

The event is a joint collaboration between the University of Manchester, Athlete������Ƶ�s Journey Home and Drug Science and is supported by the British Association for Psychopharmacology. 

The event will feature world experts in the psychedelics field:  Prof David Nutt from Imperial College London and Prof Sara Tai from The University of Manchester. 

Three elite athletes: former professional rugby player, Rory Lamont; former professional ice hockey player, Daniel Carcillo; and former mixed martial artist, Ian McCall will talk about their own healing experiences. 

Organised by Jo Neill Professor of Psychopharmacology, from The University of Manchester, the event will explore scientific and real world evidence to show that psychedelic assisted therapy (PAP) may be able to alleviate some harmful effects of trauma in elite athletes. 

Clinical studies, fieldwork and personal accounts from across the world are now finding that PAP can induce neuroplasticity - the ability of the brain to reorganise and make new connections throughout life. 

And that may treat the cognitive decline, early dementia, severe headache and pain which are so common in brain injuries. 

Prof Neill said ������Ƶ�This is particularly relevant to elite athletes in sports such as rugby, football, ice hockey, horse riding, mixed martial arts and boxing. 

������Ƶ�In addition to injury, athletes experience emotional trauma from the high pressure environment of competitive sport, and gruelling training regimes, most evident when they leave that sport. 

������Ƶ�B�ܳ� psychedelic assisted therapy is known to reduce the emotional and physical impact of these forms of trauma and is even starting to be used by elite athletes for their mental and physical health in countries where it is legal. 

������Ƶ�PAP is increasingly being recognised as a safe treatment though patients must always adhere to the law, and be well prepared in a very safe setting when taking the psychedelic medicines. They must also receive appropriate and extensive integrative therapy afterwards.������Ƶ� 

The event takes place at the University������Ƶ�s Nancy Rothwell Building on Wednesday 2nd July at 2PM. 

Dr Grace Blest-Hopley and Nige Netzband, experts on Traumatic Brain Injury who work with psychedelics will also speak to the conference. 

Professor Neill added: ������Ƶ�While most people find it extremely beneficial and indeed life-changing, PAP can be a very challenging and difficult experience for many. It is not be a medicine to be taken lightly. The treatment paradigm is 1-3 high doses in combination with therapy. Some people may not need to take this treatment again. This is very different from the current approach where people need to take a medicine every day which can have a significant side effect burden. 

������Ƶ�In spite of all the clinical and scientific evidence for their medicinal properties, particularly for disorders where nothing else works, they remain illegal Class A, Schedule 1 drugs in the UK. 

������Ƶ�The law is not evidence based and it enacts the harshest penalties for unlicensed manufacture, possession and supply. 

������Ƶ�Clinicians and scientists who want to conduct research require a controlled drugs licence from the Home Office, an expensive, bureaucratic and extremely time-consuming process. This must change.������Ƶ� 

Tickets available here, free for BAP members.

has been selected to receive the Robert Robinson Prize, while is one of this year's three Tilden Prize recipients.

Professor Larrosa and Professor Barran are among the more than 40 Research and Innovation Prize winners, which recognises researchers who have displayed their brilliance when it comes to research and innovation.

and have earned the Technical Excellence Prize for their outstanding dedication and technical expertise in running the at The University of Manchester. The prize recognises outstanding contributions to the chemical sciences made by individuals or teams working as technicians or in technical roles. 

Prof Larrosa won his prize for contributions to organic chemistry in the area of ruthenium-catalysed C������Ƶ�C bond formation, and receives ������Ƶ3,000 and a medal.

His investigates the development of catalytic processes that enable chemists in industry and academia to synthesise valuable molecules in a more straightforward and sustainable fashion. The main approach in the group involves the application of analytical tools to the detailed study of the modes of operation of transition metal catalysts, and then using this new knowledge to develop more powerful and efficient catalysts.

After receiving the prize, Prof Larrosa said: ������Ƶ�It is such an honour to receive the Robert Robinson Award, especially given its history of celebrating transformative contributions to organic chemistry. This recognition reflects the creativity, persistence and collaborative spirit of the brilliant researchers I have had the privilege to work with over the years. I am proud of what we have achieved together, and deeply grateful for the support of my colleagues, mentors and the wider scientific community.������Ƶ�

Professor Barran was recognised with the Tilden Prize for her work on the application of ion mobility mass spectrometry to complex biological systems, and breakthroughs in biomarker discovery ������Ƶ� notably non-invasive sampling to diagnose Parkinson's disease.

Her focuses on developing advanced mass spectrometry techniques to study the structure and behaviour of proteins and other biomolecules, with applications in understanding the fundamentals of biology, the mechanistic reasons for diseases and the development of therapeutics and diagnostics. One of our most notable achievements is the collaborative work with Joy Milne, a retired nurse who possesses an extraordinary sense of smell and noticed a distinct odour associated with Parkinson������Ƶ�s disease.

This observation led to research demonstrating that sebum, an oily substance secreted by the skin, contains compounds that can serve as biomarkers for Parkinson������Ƶ�s. Using mass spectrometry, our team identified specific molecules in sebum that differ between individuals with and without Parkinson������Ƶ�s disease. This discovery has paved the way for the development of a non-invasively sampled and rapid diagnostic test that can detect Parkinson������Ƶ�s disease with high accuracy, potentially allowing for earlier intervention and treatment.

Prof Barran won ������Ƶ5,000 and a medal. 

After receiving the prize, Prof Barran said: ������Ƶ�I was absolutely thrilled! This prize was formally won by both my PhD advisors, Harry Kroto and Tony Stace, my undergraduate personal tutor, Dave Garner, and many other brilliant scientists. I felt totally honoured to be among these people who I have always respected. In my case, I attribute winning to the people that I have been privileged to work with. I noted that out of about 200 recipients I was the ninth female. This also made me feel pretty pleased!������Ƶ�

Dr Muralidharan Shanmugam and Adam Brookfield are two EPSRC National Research Facility (NRF) for Electron Paramagnetic Resonance Spectroscopy technical specialists named as the winners of one of the Royal Society of Chemistry������Ƶ�s team prizes, which celebrate discoveries and innovations that push the boundaries of science.

The duo have been recognised for their outstanding dedication and technical expertise in running the facility at The University of Manchester. Electron paramagnetic resonance (EPR) is the spectroscopic technique that is selective and sensitive to unpaired electrons. The unpaired electrons could be intrinsic to the materials studied or could be induced via a process (e.g light/heat/chemically) to provide information on structure, kinetics and much more, with applications covering all areas of physics, chemistry, biology and materials science. The technical team at the EPSRC NRF both maintain the equipment and assist users with the design, implementation and analysis of proposed experiments.

They will share ������Ƶ3,000 and receive a trophy.

 After receiving the prize, Adam Brookfield said: ������Ƶ�Both Murali and I are over the moon that our contributions have been recognised by the RSC with this award.

"We're both nosey scientists at heart, we want to provide the best instrument access and knowledge to our users to enable their world-class science. We're in a unique position where we get to see and adapt the facility to the trends and hotspots in research areas, alongside training the next generation of scientific leaders.������Ƶ�

The Royal Society of Chemistry������Ƶ�s prizes have recognised excellence in the chemical sciences for more than 150 years. This year������Ƶ�s winners join a prestigious list of past recipients in the RSC������Ƶ�s prize portfolio, 60 of whom have gone on to win Nobel Prizes for their work, including 2022 Nobel laureate Carolyn Bertozzi and 2019 Nobel laureate John B Goodenough.

Dr Helen Pain, Chief Executive of the Royal Society of Chemistry, said: ������Ƶ�The chemical sciences cover a rich and diverse collection of disciplines, from fundamental understanding of materials and the living world, to applications in medicine, sustainability, technology and more. By working together across borders and disciplines, chemists are finding solutions to some of the world������Ƶ�s most pressing challenges.

������Ƶ�Our prize winners come from a vast array of backgrounds, all contributing in different ways to our knowledge base, and bringing fresh ideas and innovations. We recognise chemical scientists from every career stage and every role type, including those who contribute to the RSC������Ƶ�s work as volunteers. We celebrate winners from both industry and academia, as well as individuals, teams, and the science itself.

������Ƶ�Their passion, dedication and brilliance are an inspiration. I extend my warmest congratulations to them all.������Ƶ�

For more information about the RSC������Ƶ�s prizes portfolio, visit .

CurrentBody Skin, one of the three innovative beauty technology brands owned by TBTG, has been at the forefront of home-use beauty technology globally since 2009 and is a pioneer in bringing LED light therapy to the home. CurrentBody Skin������Ƶ�s LED Light Therapy Face Mask uses 236 LEDs to emit the three most clinically recognised wavelengths for anti-ageing: red light, near-infrared and deep near-infrared. The efficacy and safety of the technology is underpinned by hundreds of clinical studies, alongside being endorsed by Doctors, dermatologists and aestheticians.

As awareness for our products grows, so does the desire for both education and science-backed beauty technology solutions. We are therefore investing heavily in clinical research for the future as the beauty technology market increasingly becomes a part of people������Ƶ�s skincare routines.

Home to one of the most active and comprehensive centres for dermatology research in the UK, The University of Manchester was an obvious partner for our next clinical study. The 12-week clinical study will commence in September 2025 and will be led by Dr. Abigail Langton, PhD, who has an established record of internationally-recognised original research in the field of skin health and ageing.

The study will see a minimum of 20 healthy adult volunteers use the CurrentBody Skin LED Light Therapy Face Mask Series 2  for 10 minutes, five times per week for a 12-week period. In conjunction with the mask, a bespoke LED device for use on the forearm has been designed and manufactured to the same specification as the face mask. This bespoke device will be used on the volunteers������Ƶ� forearms for the same duration as the face mask to support the clinical study. Participants will undergo non-invasive assessments of their face at the beginning, the halfway point and at the end of the study. In addition, small forearm skin biopsies will be taken at the start and at the end of the 12-week period.

The results from this new study will deepen our knowledge of our technology even further, leveraging pioneering techniques including biopsies of the skin to assess the extent of skin ageing and repair. It will evaluate the technology������Ƶ�s impact on photoaged skin, which is the result of long-term sun exposure over the years, often characterised by wrinkles, uneven skin tone, and dull appearance. It will focus on the impact on skin health and function on the face and forearm, including measures such as elasticity and hydration, as well as microscopic features of the forearm skin, such as epidermal thickness.

Laurence Newman, CEO of The Beauty Tech Group, commented: ������Ƶ�As the use of LED light therapy and other beauty technologies becomes increasingly commonplace in people������Ƶ�s lives, so has the increase in demand for education and proof of results. Unfortunately, imitation products, where the accuracies of wavelengths cannot be proven, have entered the beauty technology market and this is subsequently leading to confusion and misinformation. The need to validate and prove our technology is therefore more important than ever.

������Ƶ�We are addressing these challenges by ensuring each device that we produce can be traced back to its manufacturing to show the exact wavelengths in our CurrentBody Skin LED Face Mask Series 2. Partnering with one of the biggest faculties for skin in the country, and in our home city, will support our continuing journey in expanding the clinical aspect of the use of LED light therapy.

������Ƶ�This partnership not only demonstrates our commitment to leading the way in product design and development, but also shows our commitment to raise the standards across the industry. Most importantly, it aims to ensure that customers purchase high quality aesthetic products that are proven to work and are safe to use. I am proud of the work we are doing to innovate and progress the beauty technology industry, and look forward to publishing the results once the clinical trial is completed.������Ƶ�

Dr. Abigail Langton added: "We������Ƶ�re thrilled to be collaborating with The Beauty Tech Group on this pioneering study into the effects of LED light therapy on skin ageing. By harnessing cutting-edge technology and combining it with our expertise in dermatological science, we have a unique opportunity to uncover how targeted light wavelengths influence the biology of photoaged skin. This research will generate powerful new insights into skin structure and function, helping to shape the future of science-backed, at-home skin treatments."

The White Paper takes recommendations from research carried out by University of Manchester researchers based at the Manchester Centre for Audiology and Deafness (ManCAD), funded by the Alzheimer������Ƶ�s Society and supported by the  National Institute for Health and Care Research (NIHR) Manchester Biomedical Research Centre.

They found that unaddressed hearing loss is highly prevalent in care homes, impacting on residents������Ƶ� quality of life.

The research identified several barriers relating to caregivers������Ƶ� knowledge of hearing loss and opportunities for care homes to work with audiologists. Unclear responsibilities relating to hearing care and residents������Ƶ� difficulties adapting to, or being comfortable wearing, hearing aids were also identified.

Titled ������Ƶ�Hearing Loss in Care Homes ������Ƶ� A Call to Action������Ƶ�, the paper brings together nearly a decade of practical experience from Engage������Ƶ�s work across over 35 care homes, alongside extensive research and insights from Nightingale Hammerson, where the Engage project has been running for over three years.

With at least 80% of residents in older people������Ƶ�s care homes living with hearing loss, the paper highlights the widespread impact of unaddressed hearing needs ������Ƶ� from increased risks of dementia and falls, to social isolation, depression, and avoidable distress.

Professor Martin Green OBE, Chief Executive of Care England, said: ������Ƶ�Hearing loss has long been overlooked in care settings, despite its profound impact on wellbeing, safety, and social connection. This white paper, developed jointly with Engage and Nightingale Hammerson, is a timely and vital resource for the sector. It provides practical, evidence-based recommendations that care providers can implement to deliver more compassionate, inclusive and effective care.������Ƶ�

The paper sets out a comprehensive set of evidence-informed recommendations including:

• Conducting environmental audits to reduce noise and improve lighting;
• Implementing clear protocols for hearing aid support and maintenance;
• Providing experiential hearing loss training for staff;
• Appointing Hearing Loss Champions to embed best practice;
• Ensuring access to personal amplifiers when hearing aids are not tolerated or unavailable;
• Improving access to audiology services and earwax removal;
• Supporting residents and families to explore and use assistive hearing technologies;
• Embedding person-centred communication, particularly for people living with dementia.

Dr Hannah Cross, Research Associate, Manchester Centre for Audiology and Deafness (ManCAD) at The University of Manchester, said: ������Ƶ�Hearing care that is personalised, provided consistently and dementia appropriate can make huge changes to residents������Ƶ� quality of life, wellbeing, independence and functioning.

"Meeting the hearing needs of care home residents with dementia is vital in maintaining their communication abilities, independence, and quality-of-life. 

"My PhD work outlined just how complex providing hearing care can be and how much needs to change. This White Paper will help to guide care homes in supporting their residents, and boost the priority of hearing loss within Social Care policy and regulation.������Ƶ�

Padraic Garrett, Head of Engage and Andrew Goodwin, Service Manager for Engage, said: ������Ƶ�When residents with hearing loss are not adequately supported, it leads to increased anxiety, depression, and social isolation, with higher risks to physical health issues including falls. From our many years of successfully collaborating with homes, our motivation for this Paper is to share what we have found works to address the suffering of residents with hearing loss.������Ƶ�

Nuno Santos Lopes, Director of Research and Innovation at Nightingale Hammerson, added: ������Ƶ�Hearing loss is common to the vast majority of older people with care needs and the levels of knowledge of the care givers remains very low. From creating the right environment to get staff, managers and relatives knowledgeable about how to engage with someone with hearing loss, there is a lot of work to do and this document works as an easy to access guidance to help improving the hearing care standards.������Ƶ�

The paper not only outlines an ethical and clinical imperative but also makes a compelling financial case: improved hearing care can reduce falls, mitigate cognitive decline, and enhance resident and staff wellbeing������Ƶ�ultimately supporting occupancy, reputation, and staff retention.

Care England urges all care providers to read the paper and implement its recommendations, using it as a foundation for improving practice and a platform to advocate for better audiology provision within local health systems.

Triangle CERSI is one of five Food and Drug Administration (FDA)-funded centres across the US, designed to promote innovation in regulatory science and accelerate access to complex emerging technologies. Located in Research Triangle Park, North Carolina, Triangle CERSI is a partnership between University of North Carolina at Chapel Hill and Duke University, in collaboration with North Carolina State University, North Carolina Central University, and the Burroughs Welcome Fund.

UK CEiRSI, jointly funded by InnovateUK and the Medical Research Council (MRC), operates under the leadership of the Christabel Pankhurst Institute in partnership with Unit M. This pioneering consortium has established a comprehensive national network that unites elite academic institutions������Ƶ�including University of Oxford, University of Cambridge, University College London (UCL), University of Edinburgh, University of Strathclyde, Queens University of Belfast and Swansea University������Ƶ�with key regulatory bodies such as the Medicines and Healthcare products Regulatory Agency (MHRA), National Institute for Health and Care Excellence (NICE) and Health Research Authority (HRA). With participation from 85 additional national and international stakeholders spanning academia, industry, and regulatory affairs, UK CEiRSI represents an unprecedented collaborative effort to integrate robust in-silico evidence into medical product development and regulatory decision-making pathways.

Professor Alejandro Frangi, Executive Director of UK CEiRSI, expressed his enthusiasm for the collaboration: ������Ƶ�This partnership represents a strategic milestone in global regulatory harmonisation. Triangle CERSI's pioneering work in virtual imaging trials and pharmaceutical regulatory science perfectly complements our comprehensive in silico capabilities across drugs and medical devices. By synchronising our regulatory approaches across continents, we're not simply sharing knowledge������Ƶ�we're building a unified scientific foundation that will accelerate innovation, reduce redundancy, and ultimately deliver safer, more effective medical technologies to patients worldwide. Together, we're transforming regulatory barriers into bridges.������Ƶ�

Christin Daniels, Executive Director of Triangle CERSI, highlighted the importance of the partnership: "Partnering with UK CEiRSI creates a synergistic alliance to modernize regulatory science. Ensuring faster, safer solutions for patients worldwide requires a unified regulatory language. By combining Triangle CERSI������Ƶ�s expertise in pharmaceutical evaluation and safety, clinical trial optimization, in silico models and other New Approach Methodologies with UK CEiRSI������Ƶ�s impressive national network focused on comprehensive in silico technologies, we aim to close the gap between the pace of innovation and speed of adoption along the regulatory pathway on both sides of the Atlantic."

The MOU sets the stage for a series of joint initiatives, including workshops, training programs, and collaborative research projects. These efforts will not only advance regulatory science but also contribute to the development of a skilled workforce capable of navigating the complexities of modern healthcare. 

• "In-Silico"  is a term used to describe experiments or studies that are performed using computer simulations or software. 
• For more information visit: UK CEiRSI LinkedIn ; UK CEiRSI ;  InSilicoUK ; UK CEiRSI | InSilicoUK ; In Silico Trials, Real Impact! ; Triangle CERSI

The Vera C. Rubin Observatory in Chile, has released a series of extraordinary images, which show millions of galaxies, stars in the Milky Way and thousands of asteroids, all in unprecedented detail.  

These images, captured in just 10 hours of observations, offer a glimpse of what������Ƶ�s to come from Rubin������Ƶ�s forthcoming Legacy Survey of Space and Time (LSST) - a 10-year mission to build the most detailed time-lapse map of the night sky ever attempted.

The UK is playing a major role in the global collaboration, as the second-largest international contributor to the project, supported by a ������Ƶ23 million investment from the Science and Technology Facilities Council (STFC).

The UK will host one of three international data facilities to support management and processing of the unprecedented amounts of data that Rubin will produce.

Among the UK scientists closely involved is Professor Chris Conselice, Professor of Extragalactic Astronomy at The University of Manchester. Professor Conselice sits on the UK:LSST/Rubin Board and has contributed to key scientific analyses for preparation of the data, including techniques to detect very diffuse light around galaxies and how the data from Rubin can be used with Euclid - another international satellite mission to map the dark universe.

The images have been taken with the LSST Camera - the world������Ƶ�s newest and most powerful survey telescope, equipped with the largest digital camera ever built and feeds a powerful data processing system.

Over the next decade, it will repeatedly scan the sky to create an ultra-wide, ultra-high-definition time-lapse record of our Universe that will bring the sky to life with a treasure trove of billions of scientific discoveries. The images will reveal asteroids and comets, pulsating stars, supernova explosions, far-off galaxies and perhaps cosmic phenomena that no one has seen before.

Already, the camera has identified more than 2000 never-before-seen asteroids in our Solar System.

The project will generate the largest dataset in the history of optical astronomy. The amount of data gathered by Rubin Observatory in its first year alone will be greater than that collected by all other optical observatories combined.

The dataset is expected to reach around 500 petabytes and catalogue billions of cosmic objects with trillions of measurements that will help scientists make countless discoveries about the Universe and will serve as an incomparable resource for scientific exploration for decades to come.

The University of Manchester������Ƶ�s involvement continues to shape global narratives of Egypt������Ƶ�s forgotten cities, bringing the ancient Delta back into view one discovery at a time.

In addition to Dr Nicky Nielsen, the excavation team comprised Dr Hamada Hussein (University of Sadat City), Dr Diana T. Nikolova (University of Liverpool), Matei Tichindelean (UCLA), Kylie Thomsen (UCLA), Omar Farouk, Jamal el-Sharkawy, Ahmed Fahim and Ali Bashir.

The Tower was taken out of service in 2021 with demolition beginning in 2024. It was completed in Spring 2025, with the demolition carried out by Manchester-based company P.P. O������Ƶ�Connor. 

Modern and high-quality student accommodation will be built on the site, bringing the wider Fallowfield Campus offering up to 5,400 student beds. The project will deliver 3,300 updated bedspaces as well as replacing some of the existing accommodation. 

Planning permission for the new accommodation was secured following public consultation with local groups, residents, staff and students. 

Owens Park Tower will be remembered fondly as a focal point of the Fallowfield Campus by former residents and alumni of The University of Manchester. 

Built in the 1960s, Owens Park housed thousands of students every year, and previous famous residents include actor Benedict Cumberbatch, comedian Rik Mayall, and Radiohead guitarist Ed O'Brien. 

Barra Mac Ruairí, Chief Property Officer at The University of Manchester said: ������Ƶ�Owens Park Tower will always be remembered by generations of staff and students. For many of our alumni, it was their first home in this city.  

������Ƶ�B�ܳ� a great new chapter awaits our Fallowfield Campus, and I am excited to see our bold vision for modern student accommodation, which reflects our commitment to providing an exceptional living environment, come to life.������Ƶ� 

Along with Owens Park, Oak House and Woolton Hall will eventually also be redeveloped. The changes come at a time of increasing demand for student accommodation in Manchester, with the University committed to providing inclusive and safe accommodation in sociable surroundings.  

The consortium Virdis (comprised of John Graham Construction Ltd, Equitix and Derwent FM) is driving the Fallowfield Campus redevelopment project forward in line with the University������Ƶ�s aspiration to create a greener, more sustainable future at the campus, rooted in the delivery of an unrivalled student experience. 

Dr Simon Merrywest, Executive Director for the Student Experience at The University of Manchester, said: ������Ƶ�Every student that studies with us deserves a safe place to call home and a learning environment that supports them in reaching their full potential. We are investing in our Fallowfield Campus to ensure it meets the needs of our students. 

������Ƶ�We are always listening and working to improve the experience of our students, and we understand the availability of high-quality, good value student accommodation is insufficient in this city. The changes to our Fallowfield Campus will bring seismic benefits to our student community, from the moment they arrive to the day they graduate.������Ƶ� 

In a new report from the Northern Health Science Alliance, partly based on research by University of Manchester experts entitled ������Ƶ�Ageing in the North������Ƶ�, researchers have catalogued an ������Ƶ�alarming������Ƶ� range of disadvantages faced by older people living in the North, in areas such as health, life expectancy, housing, nutrition, employment, and social isolation.

The authors stress that this inequality is mainly driven by economic and social factors, and is ������Ƶ�totally reversible������Ƶ� - as long as policymakers are bold enough to act. For example, targeted investment has the potential to reduce or recover as much as ������Ƶ10.9 billion in lost productivity costs, ������Ƶ315 million in NHS costs from falls and hip fractures, and ������Ƶ588 million in NHS costs from treating conditions resulting from poor  housing.

������Ƶ�Ageing in the North������Ƶ� is published by the Northern Health Science Alliance������Ƶ�s Ageing North network - including a multi-disciplinary team from Durham University, Lancaster University, The University of Manchester, Newcastle University, and the University of Sheffield - and Health Equity North. The team features expertise from a wide range of disciplines, from biology to sociology.

Researchers analysed existing data through a regional lens to examine the different ways in which ageing is experienced across England. They explored issues such as poverty and employment, health expectancies, long-term chronic conditions, frailty and falls, physical activity, nutrition, dementia and cognitive frailty, social support and unpaid care, social isolation and loneliness, housing and ethnicity.

The report - which you can read in full - states that:

●     There are an estimated 904,200 economically inactive 50-64 year olds in the North: 170,100 in the North East, 428,600 in the North West, and 305,500 in Yorkshire and the Humber, contributing to a potential reduction in GDP of ������Ƶ10.9 billion per year

●     People from the South are more likely to retire, while those in the North are more likely to leave the job market due to poor health

●     Older people living in the North East and North West are 1.61 and 1.33 times, respectively, more likely to be frail, 1.16 and 1.06 times more likely to have a fall that requires hospital treatment, and 1.14 and 1.12 times more likely to have a hip fracture compared to older people living in the South East

●     The cost to the NHS of falls and hip fractures in the North is NHS ������Ƶ55.7 million and ������Ƶ258.8 million per year respectively

●     1.47 million northern homes are considered non-decent, with over a third housing over-60s residents. This is costing the NHS approximately ������Ƶ588 million in treatment per year

●     In the ten years from 2012 to 2022, the North East and Yorkshire and the Humber have seen the rates of poverty among people aged 65 and over rise by 10%

●     People aged 65 or over are 5% more likely to be deprived in the North (68%) than in the South (63%)

●     Between 2020-21 and 2022-23, pensioner couples in the North East had an average income 14% lower than the national average and 25% lower than those in the South East

●     Men aged 65 and over in the North East are predicted to have the highest number of unhealthy years of life on average, at 20.2 years. Yorkshire and Humber have 19.1, while the South East has 16.6

●     The number of unhealthy years of life for older women in the North East is 23.7 years, compared to 19.4 years in the South East

●     There is a two-year life expectancy gap between the North and the rest of England, with premature death rates 20% higher for those in the North

●     Arthritis is more common amongst 55-64 year olds in the North (28%) than in the South (23%). Just 51% of people in the North East and Yorkshire and the Humber are seen for treatment within the national three-week target, compared to 79% in the South West

●     Physical inactivity in the North East among 55-74 year olds is at 31% compared to 22% in the South East

●     Northern adults over 65 are 27% more likely to experience food insecurity than those in the South

●     Cognitive frailty (cognitive impairment plus physical frailty) in old age is more common in the North than in the South, with 11.8% living with cognitive frailty in the North East compared to 7% in the South East.

●     Older adults in the North are 23.3% more likely to experience loneliness compared to the South, with northern women 1.55 times more likely to be lonely than men

●     The three northern regions have the highest proportion of people aged 65 and over living in care homes, costing an estimated ������Ƶ4.83 billion in care home fees

●     Minoritised ethnic groups consistently report poorer self-rated health than White British peers. Self-rated health is generally poorer in the North than in London and the South.

The report is being launched at an event in Westminster today (Monday, June 23, 2025) hosted by MP for Shipley, Anna Dixon, who wrote the Foreword.

Anna Dixon, Member of Parliament for Shipley, said: "Where you live shouldn������Ƶ�t affect your experience of ageing. This report brings into sharp focus the reality of how unequal ageing is across England. If we want to create a society that supports everyone to live and age better, we need to tackle the wider societal issues that result in some people in some communities dying earlier and living longer in poor health. This needs a life course approach, from childhood to adulthood, that enables people to remain active, stay healthy and contribute to society for as long as possible.������Ƶ�

Leading academics behind the report are now calling on the Government to recognise the  challenges faced by people in later life and to prioritise tackling the root causes of unequal ageing. The report includes evidence-based policy recommendations, which could go a long way to reversing the widening inequality gap between North and South.

These recommendations include:

●     Adopting a cross-government approach to prevent unequal ageing, looking at themes such as education, housing, employment and health

●     Strengthening place-based collaboration between local government, combined authorities, housing developers, the NHS, and older adult

●     Developing and delivering a national housing strategy for older people that prioritises ageing in place and invests in age-friendly, accessible homes

●     Significantly increasing investment in adult social care in the North of England

●     Developing an NHS-led, UK-wide strategy to address physical inactivity as a key driver of later-life health inequalities

●     Producing a national strategy to recognise and address cognitive frailty as a preventable condition distinct from dementia

●     Identifying the regions most at risk of diseases such as arthritis, cardiovascular disease and diabetes, and adopting a proactive preventative strategy which expands community-based services and strengthens early intervention

●     Expanding workplace health programmes and improving healthcare access disparities

●     Developing tailored place-based strategies to reduce loneliness among older people, focusing on groups at highest risk, such as women, minoritised ethnic groups, people who are living alone, or with poor health

●     Addressing food insecurity in later life through stronger national tracking and targeted local action

●     Improving the collection and use of ethnicity and regional data across health and care systems to better understand and inform culturally-appropriate and regionally-sensitive responses

●     Strengthening support for unpaid carers of older people by increasing carer������Ƶ�s allowance and carer-related benefits.

Emeritus Professor Alan Walker, from the University of Sheffield������Ƶ�s Healthy Lifespan Institute, said: ������Ƶ�This report paints an alarming picture of how inequality has eaten away at the quality of life of so many older northerners. In almost every aspect we investigated, there is a yawning gap between the North and the South - from their income and health to their housing, social care and sense of isolation.

������Ƶ�This gap is hardly new, but the most frustrating thing about it is that it is totally reversible - assuming that policymakers are willing to take decisive steps to address these issues, and provide a better life for our family members, friends, and neighbours as they age.������Ƶ�

Professor Chris Todd, from The University of Manchester, said: ������Ƶ�The country has faced several crises in recent years, from austerity to the COVID-19 pandemic. Older people in the North have carried more than their fair share of that burden.

������Ƶ�The reality is now stark. Older people in the North are more likely to be poorer, and to live shorter, less-healthy, more isolated lives in sub-optimal accommodation.

������Ƶ�The gap is growing every day. We need proactive policies - targeted at areas of greatest need - to reverse this trend and enable the North to age with hope, rather than inequality.������Ƶ�

Professor Carol Holland, the Director of Lancaster University������Ƶ�s Centre for Ageing Research, said: ������Ƶ�Unequal ageing is not inevitable. The gulf between North and South has been created and exacerbated by long-term national policies. And it can be reversed in the same way.

������Ƶ�The evidence presented in this report does not merely highlight all the ways that people experience ageing differently in the North and South. It offers a clear call to action, to make it a national priority to address this inequality - and vastly improve the lives of millions. We know a lot about prevention and risk reduction of later life difficulties such as frailty or cognitive impairment: it is not enough to claim that nothing can be done. It is time to be bold, and do better.������Ƶ�

Professor Barbara Hanratty, Professor of Primary Care & Public Health at Newcastle University, said: ������Ƶ�For many, it is harder to grow old in the North than in the South. There are some deep-seated and long-term reasons for that. But we must also acknowledge that the situation is being influenced by decisions that are being made today.

������Ƶ�Average earnings in the North amongst those aged 65 and over are the lowest in England, and poverty has increased over the last ten years. People in the North are more likely than their neighbours to leave the workforce due to ill-health. We need real policy changes to tackle the root causes of this inequality, with more targeted initiatives to address the many disadvantages facing older people in the North.������Ƶ�

Professor Charlotte Clarke, Associate Pro-Vice-Chancellor (Health) at Durham University, said: ������Ƶ�The factors that contribute to the struggles faced by older people make their presence felt far earlier - in childhoods and adulthoods where poverty, poor housing, ill-health and other disadvantages are all too common.

������Ƶ�It is absolutely essential that policymakers act to help our older citizens. But they must also recognise that these issues are the result of lifelong experiences and inequalities. To achieve real tangible change, we need policies that improve lives as a whole - and tackle these issues long before they escalate.������Ƶ�

Hannah Davies, Chief Executive of the Northern Health Science Alliance and Executive Director of Health Equity North, said: ������Ƶ�The North is a beautiful place to grow old. We have some of the most breathtaking scenery in the country, as well as welcoming and tight-knit communities. And yet, the day-to-day reality of ageing for many northerners is far harder than it should be.

������Ƶ�We have often talked about the inequalities that exist in the North, and this report is a reminder of why the gap between North and South continues to widen. There is clear evidence of this on so many fronts - from poverty levels to housing quality, frailty, nutrition, and social support. The divide is particularly pronounced amongst older adults from diverse ethnic backgrounds, which highlights the need for culturally-sensitive solutions which recognise community needs.

������Ƶ�It is undeniable that we need to offer urgent help to older people who are dealing with these issues. It is also our responsibility to make sure that future generations do not have to go through the same challenges - with targeted, considered policies that address the lifelong issues that are so familiar to northern citizens.������Ƶ�

Read the full ������Ƶ�Ageing in the North������Ƶ� report here:

The fellowship is the College������Ƶ�s highest award for non-GPs and previous fellows include Sir Chris Whitty, Sir Michael Marmot, three former presidents of the Royal College of Psychiatrists and the TV chef Jamie Oliver. 

 Nav who is also Director of the UK������Ƶ�s National Confidential Inquiry into Suicide and Safety in Mental Health and Honorary Consultant Psychiatrist at Mersey Care NHS Foundation Trust said: 

������Ƶ�I������Ƶ�m delighted to be awarded the Fellowship.  At medical school I only really considered two career paths ������Ƶ� psychiatry and general practice ������Ƶ� and it could have gone either way!  So to be recognised by the Royal College of General Practitioners feels really special.  I������Ƶ�m very grateful to them and the people who nominated me.  

������Ƶ�I would like to thank all my colleagues, patients, carers and others who have helped with our research.  I also want to thank my family, especially my big brother Sanj, a fantastic GP who retired recently and without whom I would never have become a doctor.������Ƶ� 

The fellowship means that Nav now has the letters FRCGP (Hon)������Ƶ� after his name. 

The citation for the Fellowship from the Royal College of General Practitioners highlighted Nav������Ƶ�s world leading suicide prevention research as well as his work for NICE, the UK Department of Health, and health services.  

The citation went on to say: ������Ƶ�All of his research has had a clinical real-world focus and much of it is relevant to primary care. His work has identified suicide prevention as a core safety responsibility of health and social care services.  He has been a long-standing friend of general practice and his work has most certainly led to enhanced GP care for people presenting with mental health concerns������Ƶ�

Published by HESA, the register is the most comprehensive dataset of its kind, providing the first open and auditable record of spinout activity across the UK������Ƶ�s higher education sector. It captures all spinout companies established by UK universities between 2012/13 and 2023/24, offering a robust measure of how effectively research is being translated into commercial ventures.

The University of Manchester������Ƶ�s performance reflects more than a decade of sustained effort to support its researchers in building successful, impactful businesses from world-class academic work. Driven by The University of Manchester Innovation Factory, 122 spinout companies were established during the period covered by the register, in fields ranging from advanced materials and biotech to environmental innovation.

The Innovation Factory plays a central role in this success. As the University������Ƶ�s Technology Transfer Office (TTO), the Innovation Factory is responsible for the commercialisation of the University������Ƶ�s research. This includes supporting the creation and development of spinout companies based on ideas and discoveries generated by the University������Ƶ�s academics.

Dr Catherine Headley, CEO of the Innovation Factory, said: ������Ƶ�This is a fantastic recognition of the strength of our innovation community in Manchester. It shows not just how many spinouts we������Ƶ�re helping to launch, but the real value of the support we offer to researchers with great ideas. 

"We������Ƶ�re proud to see so many of those ideas becoming successful businesses, and we������Ƶ�re committed to helping even more of them make that journey. In doing so, we������Ƶ�re building on Manchester������Ƶ�s long history of innovation and helping to secure the city������Ƶ�s future as a global centre for discovery and enterprise.������Ƶ�

The Innovation Factory provides a full spectrum of technology transfer services, including early-stage evaluation, intellectual property management, licensing, company formation and investor support. It works closely with academic teams, industry partners and investors to ensure that ideas with commercial potential receive the guidance and support they need to succeed.

The HESA Spinout Register has been developed in partnership with Jisc, Research England and the University Commercialisation and Innovation Policy Evidence Unit at the University of Cambridge. It is based on validated institutional returns to the Higher Education Business and Community Interaction (HE-BCI) survey and represents the first national resource of its kind.

The University of Manchester������Ƶ�s position in the register highlights its commitment to delivering impact through innovation and its leadership in turning research into economic and societal value.

For more information, visit the Innovation Factory .

Now live across five berths in North Harbour������Ƶ�with additional capacity to expand������Ƶ�the installation is expected to reduce up to 60,000 tonnes of CO₂ equivalent over the next 20 years. This saving is equivalent to removing approximately 2,140 cars from the road each year. also sets out how UK Government policy changes could support faster deployment of shore power at other ports.

The success of the project not only helps Aberdeen advance its ambition to become the UK������Ƶ�s first net zero port by 2040 but also demonstrates the crucial role university research plays in real-world climate solutions. Dr Bullock and the Tyndall team������Ƶ�s sustained involvement from early research to full deployment highlights the lasting value of academic contributions to national decarbonisation efforts.

The project, known as Shore Power in Operation, is part of the UK Department for Transport������Ƶ�s Zero Emission Vessels and Infrastructure (ZEVI) competition, delivered through UK SHORE and Innovate UK. With ������Ƶ4 million in funding and extensive collaboration between industry and academia, it represents a landmark public-private investment in cleaner port infrastructure.

Port of Aberdeen led the initiative in partnership with a broad consortium including OSM Offshore, Tidewater Marine UK Ltd, ������Ƶed Places Catapult, and researchers from the Tyndall Centre based in the University of Manchester, with support from Buro Happold and Energy Systems Catapult. PowerCon, a global leader in shore power solutions, delivered the on-site infrastructure.

As nations around the world aim to meet climate targets set by the Paris Agreement, the researchers highlight that without careful planning, effort to cut emissions could unintentionally maintain or widen existing regional gaps in access to services, such as how energy and water are distributed.

To help address this, the team have developed a framework, published in the journal , which uses artificial intelligence tools combined with detailed country-scale digital twin simulators to help identify infrastructure intervention plans that reduce emissions while fairly managing access to vital services like electricity and water, and improving food production.

The approach aims to help achieve sustainability and climate targets, particularly in countries with complicated interdependencies between sectors and inequitable access to services. It helps ensure that no region or community is left behind in the journey to net zero and supports UN Sustainable Development Goals.

Using a case study of Ghana, the research shows that reaching a fairer, low-carbon energy transition will not only require increased investments in renewable energy and transmission infrastructure but also more informed social, economic, and environmental planning. Countries must consider who benefits from infrastructure investments ������Ƶ� not just how much carbon they cut.

This research was published in the journal Nature Communications.

Full title: Delivering equity in low-carbon multisector infrastructure planning

DOI:

Link:

������Ƶ�It������Ƶ�s encouraging to see Manchester climb to 7th in the world for international research collaboration,������Ƶ� said Professor Colette Fagan, Vice-President for Research. ������Ƶ�The University������Ƶ�s research excellence is rooted in a culture of curiosity, collaboration and purpose, and the international collaborations of our academics across the globe is crucial for advancing research and tackling some of the major issues facing the world today.������Ƶ�

The University������Ƶ�s social and environmental impact is ranked in the top ten globally with the university being the only institution in the world in the top 10 in for both the  and ). In 2025, the University was ranked in first place in the UK and Europe and second in the world for benefitting society and the environment by Times Higher Education for the third year running. 

For further information, visit the website.

The University tops both the global league table of publications and citations at 177 and 12,313 respectively. 

The output was predominantly driven by Professor David Denning from The Manchester Fungal Infection Group (MFIG) at the The University of Manchester, the most published and most cited author at 89 papers and 9850 citations.

 He was followed by Thomas J. Walsh from the United States at 72 papers and 6,036 citations, and Dimitrios P. Kontoyiannis also from the United States ranking third at 66 papers, 6404 citations. 

Invasive aspergillosis a potentially lethal infection, usually of the lungs, is thought to affect over 2 million people each year. 

According Professor David Denning, one of the world������Ƶ�s leading experts on fungal disease, global outcomes for patients with invasive aspergillosis have improved markedly in recent years.

The success, he argues, is partly down to the huge amount of research activity devoted to the topic in Manchester and at centres across the globe. Professor Mike Bromley, Head of MFIG said: ������Ƶ�We have made significant inroads to improving outcomes for patients suffering from the devastating diseases caused by Aspergillus, but much more needs to be done.������Ƶ�

MFIG have recently worked with the WHO to highlight the need for additional efforts in antifungal drug and

However the disease still has a high mortality rate, particularly in immunocompromised people and those in intensive care, who can experience severe complications including bleeding and spread from the lungs to the brain.

Professor Denning said: ������Ƶ�Since I first encountered invasive aspergillosis as a trainee doctor in the mid 1980������Ƶ�s when it was poorly understood, my clinical and research focus has been focussed on improving what was then a dismal outcome for these patients.

������Ƶ�Great strides in both diagnosis and treatment have been made since 2002, with what was almost a universally fatal disease before the millennium to around 30% in the best performing hospitals.

������Ƶ�The improvement is down to major studies, agreed diagnostic criteria and application of accepted guidelines for caring for patients.

������Ƶ�However there continues to be a desperate need to build on these gains in every hospital globally so we can continue to improve the outlook for these often complex and vulnerable patients.

������Ƶ�Working with major pharmaceutical companies on the clinical development of key antifungal drugs voriconazole, caspofungin, and micafungin and the preclinical development of anidulafungin, posaconazole and isavuconazole has been an extraordinary journey.������Ƶ�

The figure of 177 papers dwarfs the others in the top 4:  Radboud University Nijmegen in the Netherlands published 92 papers, MD Anderson Cancer Center in Houston 90 papers, and the University of Texas 81 papers.

This research is supported by three major units at The University of Manchester:  the Manchester Fungal Infection Group (MFIG), the National Aspergillosis Centre and the Manchester Mycology Reference Centre.

MFIG has recently been awarded some significant research grants: Prof Bromley, Dr Bertuzzi and Dr Bottery of MFIG have recently received 3 awards, totalling over ������Ƶ2 million from the Wellcome Trust to explore new ways of combatting fungal infection.

The University������Ƶ�s unique commitment to addressing the United Nations (UN) Sustainable Development Goals (SDGs) is world leading. Manchester is the only university in the world to rank in the top ten for social and environmental impact in all seven years of the Times Higher Education Impact Rankings. 

The 17 SDGs are the world������Ƶ�s call to action on the most pressing challenges and opportunities facing humanity and the natural world, and The University of Manchester������Ƶ�s consistent top ranking is recognition of its leading role in tackling them. 

In this year������Ƶ�s assessment, more universities than ever were ranked with 2,318 institutions from 130 countries being ranked against how they are addressing the most pressing challenges facing our planet.  

The ranking, is the world������Ƶ�s only one that measures universities������Ƶ� contributions to the UN SDGs and assesses their commitment to sustainability across four broad areas: research, stewardship, outreach and teaching. 

Dr Julian Skyrme, Executive Director of Social Responsibility and Civic Engagement at The University of Manchester, who leads the institution������Ƶ�s entry to the ranking, said: ������Ƶ�Each year, we submit a wealth of evidence demonstrating how we embed social responsibility across all areas of our work������Ƶ�from sustainability and cultural engagement to research impact, widening participation and the student experience. This continued recognition highlights the dedication of our entire University community to making a positive difference locally and globally.������Ƶ� 

The University of Manchester came top in the world for SDG11 ������Ƶ� Sustainable Cities and Communities. Significantly contributing to this is the investment made in four public-facing cultural institutions. Manchester Museum has recently been recognised as one of Europe������Ƶ�s leading museums after winning .  

The annual prize is one of the most prestigious museum awards in the world and Manchester Museum is the first university museum to receive it, earning recognition for the way it balances globally-significant academic research with community engagement and social responsibility.  

The University has also directly addressed the energy impact of its campus in a landmark deal to see up to 65% of its electricity demand supplied via a new renewable project. In support of SDG7 ������Ƶ� Affordable and Clean Energy and SDG12 ������Ƶ� Responsible Consumption and Production, the University is building a 104,000 solar panel farm to generate green energy and also create a significant biodiversity enhancement to previously low-grade farmland. 

The University was ranked second in the world for SDG15 ������Ƶ� Life on Land. Particularly key contributions towards this goal have come from for his climate research on restoring grasslands in the UN������Ƶ�s Decade on Ecosystem Restoration initiative. Alongside this is leading research on socially driven reforestation policies to better protect our environment. 

President and Vice Chancellor, The University of Manchester, Professor Duncan Ivison said: ������Ƶ�It������Ƶ�s a tremendous achievement for our University community to once again be recognised as the UK and Europe������Ƶ�s top-ranked university - and second in the world - in this year������Ƶ�s THE Impact Rankings. This reflects not only the depth of our commitment to social responsibility but also the passion and dedication of our staff, students, and partners who bring that commitment to life every day. 

"As we prepare to launch our new strategy, Manchester 2035, this recognition is a powerful reminder of the role we can play, both here in Manchester and around the world, in leading on addressing the major challenges of our time: advancing sustainability, tackling inequality, and supporting inclusive growth.������Ƶ� 

The University of Manchester has also, this week, been ranked 35th in the annual QS World University Rankings which evaluate over 8,000 institutions around the world. The results reflect the University������Ƶ�s international profile and continued excellence in research, with other standout performances in indicators such as the International Research Network and International Students.

Read more about The University of Manchester's rankings.

The project conducted research across five diverse schools - two secondary, two primary and one alternative provision ������Ƶ� with each the subject of a comprehensive case study.

������Ƶ�Challenges such as inadequate facilities, socio-economic barriers and gender disparities were found to hinder participation,������Ƶ� MacQuarrie and Hennessey explain. ������Ƶ�Yet the study recognised schools������Ƶ� creativity in addressing these issues through tailored programs, community partnerships and student-centred approaches.������Ƶ�

Students with special educational needs and disabilities (SEND) face ������Ƶ�unique challenges������Ƶ� including limited access to appropriate and properly funded facilities.  But the authors add: ������Ƶ�Inclusive practices - such as adapting sports to accommodate diverse abilities - demonstrate the potential for PESSPA to serve as a vital bridge in reducing inequities and promoting inclusive practice.������Ƶ�

The study revealed ������Ƶ�concerning trends in prolonged sedentary behaviour������Ƶ� with 43% of pupils surveyed found to be spending over four hours daily on screens and 23% engaging in ������Ƶ�extended sedentary activities.������Ƶ�  Further, 7.2% of pupils reported feeling lonely often or all of the time compared to , with pupil happiness at 6.4 compared to .

������Ƶ�Physical activity offers a powerful counterbalance to these challenges, enhancing mood, reducing feelings of loneliness,������Ƶ� MacQuarrie and Hennessey argue. ������Ƶ�Schools should actively address concerns by integrating engaging, movement-based activities into daily routines. Programmes that emphasise the fun and social aspects and create comfortable and accessible opportunities for physical activity can shift behaviours and cultivate healthier lifestyle patterns among students.������Ƶ�

In their article, the academics set out a series of recommendations for policymakers and educators to harness ������Ƶ�the transformative potential of PESSPA to uplift communities and catalyse generational change.������Ƶ�

These include advice to the Department for Education to ������Ƶ�prioritise safe, versatile and inclusive facilities for all schools.������Ƶ�  This could be achieved, they suggest, by launching a consultation to gauge the views of ������Ƶ�educators, practitioners and school leaders to build a national picture of how this infrastructure in schools needs to be developed and maintained at scale.������Ƶ�

To embed physical activity in school culture, the Department is encouraged to ������Ƶ�integrate PESSPA across curricula and extracurricular activities, recognising its role in fostering holistic development.������Ƶ�  MacQuarrie and Hennessey continue: ������Ƶ�Community assets can also be leveraged here, and local authorities should support schools to strengthen partnerships with local sports organisations to enhance reach and impact.������Ƶ�

To promote equity, they urge policymakers to offer tailored programmes for underserved groups, including girls and children with special educational needs. They add: ������Ƶ�As the Children������Ƶ�s Wellbeing and Schools Bill progresses, there is opportunity to embed this into legislation.������Ƶ�

And to tackle sedentary behaviours, the authors advocate ������Ƶ�the development of policies and programmes to drive awareness regarding screen time and promote active lifestyles that are valued by children and young people.������Ƶ�

 by Dr Sarah MacQuarrie and Dr Alexandra Hennessey is available to read on the Policy@Manchester website. It was included in the Youth Sport Trust's recent , along with which identified locations across England where access to play and sport need more support and encouragement.

The team designed a two-dimensional (2D) manganese-oxide/graphene superlattice that triggers a unique lattice-wide strain mechanism. This approach significantly boosts the structural stability of the battery������Ƶ�s cathode material, enabling it to operate reliably over 5,000 charge-discharge cycles. That������Ƶ�s around 50% longer than current zinc-ion batteries.

The research, published in , offers a practical route to scalable, water-based energy storage technologies.

Atomic-level control over battery durability

The breakthrough centres on a phenomenon called the Cooperative Jahn-Teller Effect (CJTE). A coordinated lattice distortion caused by a specific 1:1 ratio of manganese ions (Mn³⁺ and Mn⁴⁺). When built into a layered 2D structure on graphene, this ratio produces long-range, uniform strain across the material.

That strain helps the cathode resist breakdown during repeated cycling.

The result is a low-cost, aqueous zinc-ion battery that performs with greater durability, and without the safety risks linked to lithium-ion cells.

������Ƶ�This work demonstrates how 2D material heterostructures can be engineered for scalable applications,������Ƶ� said , lead and corresponding author from University of Technology Sydney and a Royal Society Wolfson visiting Fellow at The University of Manchester. ������Ƶ�Our approach shows that superlattice design is not just a lab-scale novelty, but a viable route to improving real-world devices such as rechargeable batteries. It highlights how 2D material innovation can be translated into practical technologies.������Ƶ�

Towards better grid-scale storage

Zinc-ion batteries are widely viewed as a promising candidate for stationary storage, storing renewable energy for homes, businesses or the power grid. But until now, their limited lifespan has restricted real-world use.

This study shows how chemical control at the atomic level can overcome that barrier.

Co-corresponding author from The University of Manchester said, ������Ƶ�Our research opens a new frontier in strain engineering for 2D materials. By inducing the cooperative Jahn-Teller effect, we������Ƶ�ve shown that it������Ƶ�s possible to fine-tune the magnetic, mechanical, and optical properties of materials in ways that were previously not feasible.������Ƶ�

The team also demonstrated that their synthesis process works at scale using water-based methods, without toxic solvents or extreme temperatures - a step forward in making zinc-ion batteries more practical for manufacturing.

This research was published in the journal Nature Communications.

Full title: Cooperative Jahn-Teller effect and engineered long-range strain in manganese oxide/graphene superlattice for aqueous zinc-ion batteries

DOI: 

The is a world-leading graphene and 2D material centre, focussed on fundamental research. Based at The University of Manchester, where graphene was first isolated in 2004 by Professors Sir Andre Geim and Sir Kostya Novoselov, it is home to leaders in their field ������Ƶ� a community of research specialists delivering transformative discovery. This expertise is matched by ������Ƶ13m leading-edge facilities, such as the largest class 5 and 6 cleanrooms in global academia, which gives the NGI the capabilities to advance underpinning industrial applications in key areas including: composites, functional membranes, energy, membranes for green hydrogen, ultra-high vacuum 2D materials, nanomedicine, 2D based printed electronics, and characterisation.

The results have been published in the journal .

Using a new two-step fabrication method, the researchers demonstrated for the first time that it is possible to create and monitor, ������Ƶ�as they switch on������Ƶ�, individual Group-IV quantum defects in diamond������Ƶ�tiny imperfections in the diamond crystal lattice that can store and transmit information using the exotic rules of quantum physics. By carefully placing single tin atoms into synthetic diamond crystals and then using an ultrafast laser to activate them, the team achieved pinpoint control over where and how these quantum features appear. This level of precision is vital for making practical, large-scale quantum networks capable of ultra-secure communication and distributed quantum computing to tackle currently unsolvable problems.

Study co-author , Department of Materials at the University of Oxford, said: ������Ƶ�This breakthrough gives us unprecedented control over single tin-vacancy colour centres in diamond, a crucial milestone for scalable quantum devices. What excites me most is that we can watch, in real time, how the quantum defects are formed.������Ƶ�

Specifically, the defects in the diamond act as spin-photon interfaces, which means they can connect quantum bits of information (stored in the spin of an electron) with particles of light. The tin-vacancy defects belong to a family known as Group-IV colour centres������Ƶ�a class of defects in diamond created by atoms such as silicon, germanium, or tin.

Group-IV centres have long been prized for their high degree of symmetry, which gives them stable optical and spin properties, making them ideal for quantum networking applications. It is widely thought that tin-vacancy centres have the best combination of these properties������Ƶ�but until now, reliably placing and activating individual defects was a major challenge.

The researchers used a focused ion beam platform������Ƶ�essentially a tool that acts like an atomic-scale spray can, directing individual tin ions into exact positions within the diamond. This allowed them to implant the tin atoms with nanometre accuracy������Ƶ�far finer than the width of a human hair.

To convert the implanted tin atoms to tin-vacancy colour centres, the team then used ultrafast laser pulses in a process called laser annealing. This process gently excites tiny regions of the diamond without damaging it. What made this approach unique was the addition of real-time spectral feedback������Ƶ�monitoring the light coming from the defects during the laser process. This allowed the scientists to see in real time when a quantum defect became active and adjust the laser accordingly, offering an unprecedented level of control over the creation of these delicate quantum systems.

Study co-author  from the University of Cambridge, said: ������Ƶ�What is particularly remarkable about this method is that it enables in-situ control and feedback during the defect creation process. This means we can activate quantum emitters efficiently and with high spatial precision - an important tool for the creation of large-scale quantum networks. Even better, this approach is not limited to diamond; it is a versatile platform that could be adapted to other wide-bandgap materials.������Ƶ�

Moreover, the researchers observed and manipulated a previously elusive defect complex, termed ������Ƶ�Type II Sn������Ƶ�, providing a deeper understanding of defect dynamics and formation pathways in diamond.

Study co-author , Professor of Advanced Electronic Materials at The University of Manchester, said: ������Ƶ�This work unlocks the ability to create quantum objects on demand, using methods that are reproducible and can be scaled up. This is a critical step in being able to deliver quantum devices and allow this technology to be utilised in real-world commercial applications.������Ƶ�

The study ������Ƶ�Laser Activation of Single Group-IV Colour Centres in Diamond������Ƶ� has been published in Nature Communications: 

The research, which included more than 270,000 people, found no such link between asthma and working nightshifts in men.

The study was by Dr Robert Maidstone from the University of Manchester, UK, and colleagues. He said: ������Ƶ�Asthma disproportionately affects women. Women generally have more severe asthma, and higher rate of hospitalisation and death from asthma compared to men.

������Ƶ�In our previous research we found a higher risk of moderate or severe asthma in nightshift workers, so we wanted to see whether there were further differences between the sexes.������Ƶ�

The researchers used data from the UK Biobank. They included a total of 274,541 working people and found that 5.3% of these had asthma, with 1.9% suffering with moderate or severe asthma (meaning they were taking an asthma preventer inhaler and at least one other asthma treatment, such as an oral steroid). They categorised these people according to whether they worked only during the day, only nightshifts, or a combination of the two.

Their analysis revealed that, overall, women who work shifts are more likely to have asthma. Women who only work nightshifts are around 50% more likely to suffer with moderate or severe asthma compared to women who only work in the daytime.

The risk of asthma in men did not alter according to whether they worked days or nights.

Dr Maidstone said: ������Ƶ�This is the first study to evaluate sex differences in the relationship between shift work and asthma. We found that permanent night shift-workers had higher odds of moderate-severe asthma when compared to corresponding day workers.

������Ƶ�This type of research cannot explain why shift work and asthma are linked; however, it could be because shift work disrupts the body clock, including the levels of male and female sex hormones. High testosterone has previously been shown to be protective against asthma, and so lower testosterone in women could play a role. Alternatively, men and women work different types of shift jobs, and this could be a factor.������Ƶ�

In postmenopausal women, the risk of moderate or severe asthma was almost doubled in night workers, compared to day workers, in those not taking hormone replacement therapy (HRT).

Dr Maidstone added: ������Ƶ�Our results suggest that HRT might be protective against asthma for nightshift workers, however further research is needed to test this hypothesis in prospective studies and randomised controlled trials.������Ƶ�

The researchers plan to study whether sex hormones play a role in the relationship between shift work and asthma by using data from the UK Biobank and from Our Future Health, a new health research programme in the UK population. 

Professor Florence Schleich from the European Respiratory Society������Ƶ�s expert group on airway diseases, asthma, COPD and chronic cough, based at the University of Liège, Belgium, and was not involved in the research. She said: ������Ƶ�Asthma is a common, long- term condition that affects millions of people worldwide. We know that women are more likely to have asthma, to have worse asthma and more likely to die from asthma, but we do not fully understand why.

������Ƶ�This research suggests that working nightshifts could be a risk factor for asthma in women, but not in men. The majority of workers will not have an easy option of switching their shift pattern, so we need further research to verify and understand this link and find out what could be done to reduce the risk for women who work shifts.������Ƶ�

Maidstone RJ, Ray DW, Liu J, et al. Increased risk of asthma in female night shift workers. ERJ Open Res 2025; in press .

The largest ever study to evaluate the comparative safety of constipation across different opioids is published today (16/06/25). 

The study was funded by the Nuffield Foundation������Ƶ�s Oliver Bird Fund, which supports research to improve the social and economic well-being of people living with musculoskeletal conditions and Versus Arthritis. It was also supported by the National Institute for Health and Care Research (NIHR). 

Morphine, oxycodone, fentanyl and combination opioids, they found, were associated with a significantly higher risk of severe constipation when compared to codeine. 

Tramadol, on the other hand, was associated with the lowest risk of constipation when compared to codeine. 

Patients on greater than 50 morphine milligram equivalent (MME) per day - a universal measure of opioid strength- experienced the highest risk of severe constipation. Fifty MME per day is roughly equal to taking either 50mg of morphine or 33 mg of oxycodone each day.

 Guidance from the UK site recommends the dose above which opioid harms likely outweigh benefits is 120 MME per day. However, this is currently under review. 

The study was carried out using hospital electronic health records of 80,475 eligible patients in Northwest England between 2009 and 2020. 

Opioid exposure was measured using administered drug information from the hospital records, and a severe constipation event was defined as an administration of an enema or suppository. 

The study authors say that being aware of the relative risks allows healthcare professionals to better tailor pain management strategies to personal needs. It also allows more informed discussions with patients about their pain relief dose and type, including choosing one with a lower risk as appropriate. 

Senior author Dr Meghna Jani, NIHR Advanced Fellow and Senior Clinical Lecturer at The University of Manchester said: ������Ƶ�Constipation is a frequent adverse event associated with opioid medications that can have a considerable impact on patients������Ƶ� quality of life. 

������Ƶ�As well as the major impact on activities of daily living, opioid-induced constipation has also been associated with longer hospital stays, higher hospital costs, and increased emergency department visits.������Ƶ�

Estimates of constipation rates within electronic health records are likely to under-represent the true prevalence both in primary and secondary health care records, the researchers find.

This is because constipation may be seen as less serious and therefore not always coded, despite being mentioned.

Patients may also struggle to openly talk about their bowel habits with a health care professional, thereby not discussing it if they get admitted to hospital, or not seeking health advice when they do experience it.

She added: ������Ƶ�Previously, we didn������Ƶ�t know enough about the risk associated with specific opioids, given the different ways they act on the body, as well as the effect of daily dose.

������Ƶ�This study will allow clinical prescribers and patients to make better shared decisions about what pain relief is best for them, to minimise the risks of this side effect of opioids, and thus improve patients������Ƶ� quality of life.

������Ƶ�If patients need to be on opioids, we urge prescribers to be cautious with opioid dosing, and aim for the lowest effective dose to manage pain while mitigating the risk of constipation and other side effects.������Ƶ�

The paper: Comparative risk of severe constipation in patients treated with  opioids for non-cancer pain: a retrospective cohort study in Northwest England is available:

Over 2000 scientists, veterinarians, technicians, and regulators from across Europe and beyond converged on Athens for the sixteenth FELASA Congress to hear BSF Director Dr Maria Kamper������Ƶ�s vision on transformational leadership. 

The Congress is held every three years in different European cities to advance excellence in laboratory animal science. 

FELASA - the Federation of European Laboratory Animal Science Associations - develops guidelines and policies on all aspects of laboratory animal science, including training programs, welfare standards, and scientific best practice. 

Representing professionals in over 28 countries across Europe, this year's Congress took place between June 2 and 5 at the Megaron Athens International Conference Centre. 

Dr Maria Kamper, Director of the BSF, spoke to a packed audience about how exceptional leadership creates excellence in laboratory animal science.

 Drawing from her philosophy that "people are the heart of our work," Dr Kamper challenged the traditional approach to facility management. 

"We don't just ask our staff to follow protocols," Dr Kamper told the Congress. "We inspire them to see themselves as guardians of breakthrough discoveries. 

������Ƶ�Every refinement they create could spare suffering for thousands of animals. They go to work knowing they are advancing human knowledge while honouring every heartbeat in their care," she added. 

The BSF's Dr Jo Stanley and Mike Addelman from the University's Directorate of Communications, Marketing and Student Recruitment also addressed the Congress on the University's sector-leading openness agenda in animal research. 

The University - officially recognized as a Leader in Openness - has developed an award-winning website and engagement programme that has become a trailblazer for the sector, demonstrating how transparency fosters public trust, enhances research integrity, promotes collaboration, and exemplifies ethical rigor in the responsible use of animals in research. 

Dr Kamper said: "Being part of FELASA was an extraordinary privilege and represents the kind of strategic leadership that looks beyond daily operations toward future possibilities.

������Ƶ�We are proud of the culture of excellence we have cultivated at Manchester - where our teams don't just meet standards, they set new ones.

 ������Ƶ�Our hope is that the transformational approach we've developed here will inspire colleagues across Europe and beyond to lead their teams toward excellence that serves both scientific advancement and compassionate animal care.������Ƶ� 

• Dr Stanley's attendance was supported by a LASA (Laboratory animal science association) bursary
• To view the presentation by Dr Kamper, click
• To view the presentation by Dr Stanley and Mike Addelman click

In recognition of its longstanding commitment to sustainability, the University will represent the UK as one of the founding members of the International Green Learning and Skills Accelerator, a Times Higher Education initiative set up as part of the

The Pact is run by three UN agencies ������Ƶ� the United Nations Environment Programme, the International Labour Organization and the UN Children������Ƶ�s Fund, UNICEF - and was established to help tackle the green skills deficit and ������Ƶ�advance the just transition to a low carbon and circular economy������Ƶ�.

The Accelerator, and a related research project, will advance this mission by bringing together universities, industries, and policymakers from around the world to share best practice and to develop a globally recognised framework for green skills and learning.

This initiative aims to define, standardise, and promote the green skills necessary for the net-zero economy, aligning education and employment to meet the challenges of the climate crisis.

Professor Duncan Ivison, President and Vice-Chancellor of The University of Manchester, said: ������Ƶ�Being invited to help shape the Green Learning and Skills Accelerator as a founding member is a powerful recognition of the University������Ƶ�s long standing leadership in sustainability ������Ƶ� and of the expertise, creativity and collaborative spirit of our staff and students.  This initiative brings together universities, city partners, industry and global institutions to tackle one of the most urgent challenges of our time.  It������Ƶ�s a unique opportunity to co-create a scalable, inclusive approach to green learning that supports the transition to a net-zero future ������Ƶ� here in Manchester and around the world.������Ƶ�

Phil Baty, Chief Global Affairs Officer at Times Higher Education, added: ������Ƶ�It is fantastic to witness The University of Manchester joining the Green Learning and Skills Accelerator programme as a founding partner representing the UK. This once more reinforces the University������Ƶ�s commitment to sustainability as witnessed by their participation in the top ten each year of our .  Times Higher Education������Ƶ�s mission is to connect people, data and insights to help universities make the world a better place and this is a prime illustration of this in practice as we move towards a green economy.������Ƶ�

One of the primary objectives of the project is to offer a consistent definition and taxonomy of what constitutes 'green skills' for the net-zero economy and how to measure it. The initiative is also in support of the Green Jobs for Youth Pact, that has seen a number of governments sign up and show their support at the UN Summit of the Future.

The University of Manchester will work alongside a select group of other global institutions to co-develop a new framework that will guide universities and employers, ensuring they have the skills and knowledge needed teach young people from the offset or re-train the current workforce the skills they need to drive the green economy.

Professor Jennifer O������Ƶ�Brien, Academic Lead for Sustainability Teaching and Learning, who has been leading on the project, said: "Universities are uniquely positioned to drive the green skills agenda through our world-class research, teaching, and partnerships. By engaging with our talented and diverse students and academics from not only our own community but across the globe, alongside our cross-sector collaborators, we are ensuring that green education is inclusive and has impact. This project will build on existing best practices and push us forward in creating thriving, sustainable futures for all, through transformative learning experiences."

As a globally connected, civic university, The University of Manchester will use its connections to bring in alumni and partners from across the world have an input into the new framework. It also hopes to feed into city-wide plans to support its ambitious zero carbon goal for 2038.

The programme will involve extensive research and collaboration with universities, industries, and policymakers with the goal of creating an  inclusive, scalable Accreditation Framework to support, guide and give recognition to universities and colleges as Green Learning and Skills Providers.

Dr Julian Skyrme, Executive Director of Social Responsibility at The University of Manchester, said: ������Ƶ�As one of the world������Ƶ�s leading universities for social responsibility and sustainable development we know that our students ������Ƶ� as future citizens, leaders and skilled professionals ������Ƶ� will play a key role in addressing the climate and nature crisis. We������Ƶ�re look forward to playing a leading role in the critical task of defining and championing the sort of education we need to create a more sustainable world.������Ƶ� 

The University of Manchester has been consistently ranked as a leader in sustainability. It is the only university in the world to rank in the top ten for social and environmental impact in every year of the .

The University has set ambitious goals to reduce its environmental impact, aligning with its core mission of social responsibility. In 2022, it divested from coal, oil, and gas, reducing the carbon intensity of its investments by 37%. All the University������Ƶ�s degree programs are aligned with the , and its research platform, which includes the , combines world-leading research across disciplines to develop sustainable solutions for urgent environmental challenges. The University also recently signed a landmark deal that will see up to 65% of its electricity demand supplied through a brand-new renewables project.

The report, presented in Helsinki on 6 June, addresses persistent barriers to public-private research and development (R&D) partnerships, and proposes a series of strategic reforms. Professor Georghiou chaired the international expert panel behind the study, commissioned as part of the EU������Ƶ�s Horizon Europe Policy Support Facility.

Speaking to an audience of 300 stakeholders from across Finland������Ƶ�s innovation ecosystem, Professor Georghiou outlined the report������Ƶ�s findings, which call for a cultural shift in academia, more robust incentives for collaboration, and streamlined government support systems. He later presented the final report personally to Finnish Prime Minister, Petteri Orpo, accompanied by cabinet ministers and business and research leaders - an indication of the importance attached to the recommendations at the highest level of government.

Professor Georghiou, part-time Associate Vice-President and Professor in AMBS, said: "While I hope that the report will be of general interest, the demonstrated importance which the Finnish government attach to the impact of university research is also significant. In a time of economic difficulty for Finland, they have nonetheless decided to increase research spending to 4% of GDP. The UK figure is currently 2.9%."

The report highlights the need to reinvigorate collaboration through long-term strategic partnerships, better incentives for researchers, and improvements to the visibility and accessibility of research infrastructure������Ƶ�particularly for small and medium-sized enterprises (SMEs). It also underscores the importance of building a skilled workforce and supporting scale-ups to remain rooted in the Finnish innovation ecosystem.

The significance of the work extends beyond Finland. The European Commission has invited Professor Georghiou to present the report at a meeting of research ministry heads from all EU and associated countries in Gdańsk, Poland, later this month.

The full report, titled Support to Finland on improving R&D collaboration between research organisations and the private sector, is available for download from the .

The report is the first to analyse the impact of the Government������Ƶ�s 2019 drive to increase the numbers of these workers, who connect patients to activities and support in their communities which boost health and well-being.

The 2019 NHS Long-term Plan pledged NHS England funding to provide 1,000 trained social prescribing link workers in place by the end of 2021 - and to ensure that every patient in England could access the service by 2022.

This National Institute for Health and Care Research (NIHR) funded study - led by researchers from The University of Manchester and co-authored with the University of Edinburgh, Newcastle University and University of Bristol- indicates that the scheme has led to improved outcomes and experience of and or both patients with long-term conditions and mental health needs. However, researchers were unable to pinpoint any noteworthy impact on loneliness and isolation.

The study combined administrative workforce data and information from the General Practice Patient Survey between 2018 and 2023, which includes more than 4.1million responses in total. It calculated the impact of adding one full-time equivalent (FTE) link worker per 50,000 patients to assess whether the NHS������Ƶ� aims for the rollout were fulfilled. The outcomes from the survey assessed for this study were:

o   Increasing the patient������Ƶ�s confidence in managing their long-term condition

o   Making them feel more supported by local services and organisations

o   Making them feel less isolated from others

o   Improving their experience with their GP

o   An increased feeling that their mental health needs were understood

The study found that for those with one or more long term conditions, patient confidence in managing their long-term condition increased, as well as feeling more supported by local services and in their overall experience with general practice.

Similar improvements were seen for those with mental health needs and in feeling that their needs were understood. However, no evidence of benefit was found for those experiencing loneliness and social isolation.

The results indicate that an increase in social prescribing provision has had a positive effect on the population level. While the figures appear low, only 3.2% of the registered GP population had actually been referred to a social prescribing service by March 2023, so being able to detect an impact of this size at the population level is ������Ƶ�clinically significant������Ƶ�.

The researchers estimated the population effects, and the findings suggest that an additional FTE social prescribing link worker per 50,000 population in all Primary Care Networks (PCNs)  - which equates to approximately one extra link worker per average PCN - was associated with an increase nationally in approximately 47,000 people reporting confidence in managing their long-term conditions and 132,000 people reporting having had a good GP experience.

However, the authors suggest that more work needs to be done to establish whether the rollout has any impact on use of hospital services, and whether there has been an impact on known health inequalities.

They also note that the initiative cost the NHS an estimated ������Ƶ130million in 2022/23, without taking onward referral costs into account. They conclude that further research is required to determine ������Ƶ�whether the scheme is financially sustainable as a whole������Ƶ�.

, Professor of Implementation Science at The University of Manchester, said: ������Ƶ�The Government������Ƶ�s plan to increase the provision of social prescribing was an attempt to tackle crucial challenges, including helping patients feel more supported, empowered, and positive about the health services available to them.

������Ƶ�As such, it is important that studies such as this exist, to assess whether initiatives have the desired effect, and that they provide the right assistance to people who are most in need of care and connection.

������Ƶ�Our results indicate that the Government������Ƶ�s focus on link worker provision has had a positive effect, and that social prescribing can help patients feel more supported by healthcare services and professionals.

������Ƶ�However, we would welcome future research into the sustainability and cost-efficiency of the scheme, particularly when more is known about its full cost including referrals.������Ƶ�

, Research Fellow in Health Economics at The University of Manchester, said: ������Ƶ�This report provides useful food for thought for policymakers assessing this scheme, and other similar initiatives designed to improve the health of the country.

������Ƶ�Considering the service has been used by a relatively small percentage of the population, the results seem to indicate that social prescribing has a notable effect on a patient������Ƶ�s GP experience and their sense that their needs are understood.

������Ƶ�However, there is still much work to do before we can determine the impact and sustainability of schemes such as this one. There is definite scope for future studies which determine whether such referrals have an effect on unplanned hospital admissions, and whether the current approach offers the best possible care for the country at an optimal cost.������Ƶ�

Charlotte Osborn-Forde, Chief Executive of the National Academy for Social Prescribing, said: ������Ƶ�This is an important and groundbreaking piece of research. There is already a wide range of evidence demonstrating that social prescribing is highly impactful and can save the NHS money, but this is the first time research has been published showing statistically significant improvements for the whole population. It������Ƶ�s simple: the more Link Workers that are employed, the more likely it is that patients are able to manage their own health, and have a good experience of their GP. 

������Ƶ�This is because Link Workers get to know patients, supporting them step by step to access local services, tackling issues like housing, debt, food or fuel poverty, loneliness and unemployment - the issues that matter to people and can have a big impact on our health. This vital research further supports the case for the expansion of social prescribing in the NHS so that is available to more patients who could benefit.������Ƶ�

The full study - entitled ������Ƶ�Impact of the rollout of the national social prescribing link worker programme on population outcomes: evidence from a repeated cross-sectional survey������Ƶ� has been published in The British Journal of General Practice. You can read the report and its results here:

Apini is a spinout from The University of Manchester developing a new treatment for chronic inflammatory diseases using a small molecule approach. The company was formed with help from the University������Ƶ�s Innovation Factory, its technology transfer office. According to the Spotlight on Spinouts 2025 report by the Royal Academy of Engineering and Beauhurst, the Innovation Factory supported the launch of 114 spinout companies between 2011 and January 2025, placing the University among the UK������Ƶ�s top institutions for spinout creation.

Spun out of the University of Manchester, Apini is developing a novel small molecule for the treatment of chronic inflammatory diseases. Potential indications include Crohn������Ƶ�s disease and Ulcerative Colitis, the two most common forms of inflammatory bowel disease (IBD), which affects as many as 10 million people worldwide. Apini is looking to address the significant unmet need in this area of medicine through targeted modulation of eNAMPT, an enzyme implicated in multiple inflammatory conditions.

Preclinical studies demonstrate the potential for selective eNAMPT modulators to treat various inflammatory diseases without inducting immune suppression.

Apini was discovered by founding scientist Professor Sam Butterworth, who is world-renowned for his work in the invention of Tagrisso, a life-saving anti-cancer drug for EGFR mutant lung cancer that is used globally.

Slingshot was built by Syncona with an initial commitment of ������Ƶ12.5 million to identify and advance de-risked therapeutic programmes from the work of leading academic researchers. Apini is the first company to work with Slingshot, following its launch in November 2024, with Northern Gritstone becoming the first co-investor.

Apini������Ƶ�s funding from Northern Gritstone and Syncona will be delivered over three tranches tied to company milestones, with the original commitment unchanged in value.

Northern Gritstone Chief Executive, Duncan Johnson, said: ������Ƶ�Apini is based on the groundbreaking drug development work of Professor Sam Butterworth from The University of Manchester, and is a fantastic example of life sciences company creation based on world-class research. We������Ƶ�re delighted to invest in Apini, alongside Syncona, and with the support of the Slingshot accelerator������Ƶ�

Founder of Apini, Professor Sam Butterworth said ������Ƶ�This investment from Northern Gritstone supports Apini������Ƶ�s mission to treat inflammatory diseases without the induction of immune suppression. We look forward to advancing and accelerating the Apini programme which we believe can bring meaningful improvements to patients across a broad range of chronic inflammatory diseases.������Ƶ�

Executive Chair of Slingshot, Edward Hodgkin added: ������Ƶ�We are delighted to welcome Northern Gritstone as an investment partner for Apini, with the investment providing further validation of this novel programme. We believe that Slingshot������Ƶ�s expertise and operational support has the ability to accelerate exceptional academic science, like Apini, into attractive biotech assets that can quickly and effectively transform into groundbreaking treatments for patients.������Ƶ�

·&�Բ�����;&�Բ�����;&�Բ�����;&�Բ�����;&�Բ�����;&�Բ�����;&�Բ�����; The unique Saint Christopher woodcut, dated 1423 ������Ƶ� the oldest known dated example of European printing.

·&�Բ�����;&�Բ�����;&�Բ�����;&�Բ�����;&�Բ�����;&�Բ�����;&�Բ�����; The Gutenberg Bible of 1454/55 - the first major book printed in Europe and a masterpiece that revolutionised the book world.

·&�Բ�����;&�Բ�����;&�Բ�����;&�Բ�����;&�Բ�����;&�Բ�����;&�Բ�����; The Mainz Psalters of 1457 and 1459 - two of the most beautiful books ever printed, both with handwritten musical notation.

·&�Բ�����;&�Բ�����;&�Բ�����;&�Բ�����;&�Բ�����;&�Բ�����;&�Բ�����; Fifteen very rare blockbooks - in which the images and text on each page were printed from a carved block of wood.

The release forms part of the ongoing Incunabula Cataloguing Project, which will eventually see all of the library's approximately 4000 15th century printed books fully catalogued, of which around 300 of the rarest and most important will be digitised and made available online. While of immense value to scholars of early print culture, the collection is also designed to engage curious members of the public with some of the most beautiful and significant books ever printed.

The Early European Print collection is part of a longstanding commitment by The University of Manchester and the John Rylands Library to share cultural heritage with the widest possible audience through Manchester Digital Collections.

, Reader in Engineering for Net Zero, is one of ten finalists to be awarded ������Ƶ100,000 in seed funding to develop his solution for this year������Ƶ�s .  

In its second year, the Manchester Prize is looking for researchers with the most impactful and innovative artificial intelligence (AI) solution enabling the UK to accelerate progress towards net zero.  

Although AI technologies are advancing rapidly, their adoption in clean energy systems has not kept pace. The Manchester Prize aims to accelerate progress by encouraging the development of AI solutions that support the UK in achieving its ambition to lead the world in clean energy. 

Dr Papadopoulos������Ƶ� solution, Grid Stability, uses AI to accelerate the analysis performed which ensures electrical power systems meet the specified stability, security and reliability criteria. 

Electrical power systems worldwide are going through unprecedented changes to achieve decarbonisation targets. This drive calls for new technologies, such as renewables, electric vehicles and heat pumps, which increases the complexity and uncertainty in power system operation. System stability is the cornerstone of power system operation, and if not carefully considered, it can lead to blackouts with high economic impact and fallout.  

The tool replaces slow, complex simulations with rapid, AI-driven assessments, enabling real-time monitoring, faster decision-making, and more confident planning. This helps grid operators maintain reliability while scaling up clean energy solutions and cutting emissions. 

Dr Papadopoulos aims to work closely with utility companies to enable safe and useful implementations of Grid Stability. 

Speaking about his solution, Dr Papadopoulos said: ������Ƶ�Grid Stability uses machine learning to help bring lower, or zero, carbon technologies onto the grid faster and at the scale we need to hit net zero, but without compromising system stability.

������Ƶ�Being named a finalist for the Manchester Prize is a huge boost; it not only validates the impact of our work but also gives us a platform to accelerate progress and collaborate more widely across the energy sector.������Ƶ�

Dr Papadopoulos recognised that the computational cost and complexity of assessing stability and security made it difficult to support real-time awareness, decision-making and optimisation. As a result, system dynamics are often neglected or oversimplified. Grid Stability, using machine learning, offers a promising solution to addressing this challenge. 

The Manchester Prize will pick its winner in Spring 2026, and the winning innovator will receive a ������Ƶ1 million grand prize to continue developing their solution. The winning solution must demonstrate not only technical innovation, but also an evidenced road map to near-term (2030) adoption and scale.  

Announced and launched in 2023, the Manchester Prize is multi-million-pound, multi-year challenge prize, which is funded by the Department of Science, Innovation and Technology. The Prize seeks to reward UK-led breakthroughs in AI for public good and continues to secure the UK������Ƶ�s place as a global leader in cutting-edge innovation. 

The Manchester Prize is named after the world������Ƶ�s first stored programme computer, nicknamed ������Ƶ�The Baby������Ƶ�, which was built at The University of Manchester in 1948. AI research at The University continues to build on this legacy, as shown by Dr Papadopoulos������Ƶ� achievement. 

The study is published today (Wednesday) in ERJ Open Research [1]. Carbon can enter the lungs via cigarette smoke, diesel exhaust and polluted air.

The cells, called alveolar macrophages, normally protect the body by engulfing any particles or bacteria that reach the lungs. But, in their new study, researchers found that when these cells are exposed to carbon they grow larger and encourage inflammation.

The research was led by and from The University of Manchester, UK, and funded by the North West Lung Centre Charity and the National Institute for Health and Care Research (NIHR) Manchester Biomedical Research Centre (BRC).

Dr Baker, Research Associate within the NIHR Manchester BRC������Ƶ�s Respiratory Theme said: ������Ƶ�COPD is a complex disease that has a number of environmental and genetic risk factors. One factor is exposure to carbon from smoking or breathing polluted air.

������Ƶ�We wanted to study what happens in the lungs of COPD patients when this carbon builds up in alveolar macrophage cells, as this may influence the cells������Ƶ� ability to protect the lungs.������Ƶ�

The researchers used samples of lung tissue from surgery for suspected lung cancer. They studied samples (that did not contain any cancer cells) from 28 people who had COPD and 15 people who were smokers but did not have COPD.

Looking specifically at alveolar macrophage cells under a microscope, the researchers measured the sizes of the cells and the amount of carbon accumulated in the cells.

They found that the average amount of carbon was more than three times greater in alveolar macrophage cells from COPD patients compared to smokers. Cells containing carbon were consistently larger than cells with no visible carbon.

Patients with larger deposits of carbon in their alveolar macrophages had worse lung function, according to a measure called FEV1%, which quantifies how much and how forcefully patients can breathe out.

When the researchers exposed macrophages to carbon particles in the lab, they saw the cells become much larger and found that they were producing higher levels of proteins that lead to inflammation.

Dr Lea, Investigator within the NIHR Manchester BRC������Ƶ�s Respiratory Theme said: ������Ƶ�As we compared cells from COPD patients with cells from smokers, we can see that this build-up of carbon is not a direct result of cigarette smoking. Instead, we show alveolar macrophages in COPD patients contain more carbon and are inherently different in terms of their form and function compared to those in smokers.

������Ƶ�Our research raises an interesting question as to the cause of the increased levels of carbon in COPD patients������Ƶ� macrophages. It could be that people with COPD are less able to clear the carbon they breathe in. It could also be that people exposed to more particulate matter are accumulating this carbon and developing COPD as a result.

������Ƶ�In future, it would be interesting to study how this carbon builds up and how lung cells respond over a longer period of time.������Ƶ� 

Professor Fabio Ricciardolo is Chair of the European Respiratory Society������Ƶ�s group on monitoring airway disease, based at the University of Torino, Italy, and was not involved in the research. He said: ������Ƶ�This set of experiments suggest that people with COPD accumulate unusually large amounts of carbon in the cells of their lungs. This build-up seems to be altering those cells, potentially causing inflammation in the lungs and leading to worse lung function.

������Ƶ�In addition, this research offers some clues about why polluted air might cause or worsen COPD. However, we know that smoking and air pollution are risk factors for COPD and other lung conditions, so we need to reduce levels of pollution in the air we breathe and we need to help people to quit smoking.������Ƶ�

[1] Baker J, Booth S, Dungwa J, et al. Alveolar macrophage carbon is associated with COPD severity. ERJ Open Res 2025; in press (https://doi.org/10.1183/23120541.00933-2024).

The paper is available here: 

Funding: the North West Lung Centre Charity and the National Institute for Health and Care Research (NIHR) Manchester Biomedical Research Centre (BRC).

Announced by the Technology Secretary on Monday 9 June), the Spärck AI scholarships, named after pioneering British computer scientist Karen Spärck Jones, will provide full funding for master������Ƶ�s degrees at nine leading UK universities specialising in artificial intelligence and STEM subjects ������Ƶ� from Edinburgh to Manchester, and Newcastle to Bristol. 

Set to rival the likes of globally recognised Rhodes, Marshall and Fulbright scholarships, at least 100 talented undergraduates level students from the UK and abroad will see unparalleled access to industry partnerships, work placements and mentorship opportunities, including in the UK������Ƶ�s AI Security Institute as well as leading tech firms like Darktrace, Faculty and Quantexa. 

This will not only drive forward AI innovation that grows the UK economy but also gives young people a direct route into highly skilled jobs in the UK������Ƶ�s tech sector. 

By covering both tuition and living expenses, the scholarship could also be of interest to talent students from low-income backgrounds who might otherwise be unable to afford university ������Ƶ� spreading opportunity across the UK. 

Technology Secretary Peter Kyle said: ������Ƶ�We are providing unique opportunities for talented young people to take up master������Ƶ�s degrees in AI, with fully funded tuition and unparalleled access to industry. 

������Ƶ�Students will be able to go on to highly skilled jobs, building a workforce fit for the future and boosting economic growth as part of our Plan for Change. 

������Ƶ�We are also expanding our fellowship programme to bring top talent into our leading AI sector and drive forward transformational benefits to the public like new drug discoveries.������Ƶ� 

Spärck AI scholarships: Applications will open in Spring 2026, with the first cohort beginning their studies in October 2026.  

Universities participating in the Spärck AI scholarship programme include: Oxford, Cambridge, Imperial College London, UCL, Southampton, Edinburgh, Newcastle, Manchester and Bristol, who will co-design and co-fund the initiative. 

Companies signed up to participate in the scholarship programme include PolyAI, Quantexa, CausaLens, Flok, Beamery, Darktrace and Faculty. 

������Ƶ�Sadly, recent media coverage about our study has been inaccurate - while more frequent sex is linked to higher relationship satisfaction, this could just as likely be because those in more satisfying relationships tend to have sex more often - not that increasing frequency alone will necessarily boost happiness. Therapeutic interventions therefore need to focus on exploring any underlying dynamics and barriers to intimacy, rather than just encouraging people to increase frequency.������Ƶ�

These findings align with similar studies conducted in other Western populations, suggesting these insights are likely applicable beyond Aotearoa/New Zealand. For sex and relationship therapists, the research suggests that focusing on interventions that increase the frequency of sex and/or improve orgasm consistency (rather than aiming for 100% every time) may be more beneficial for helping women improve their sexual relationship satisfaction - however, the authors highlight that this requires further research.

Ultimately, removing the pressure and goal-oriented mindset around orgasm may enhance both sexual pleasure and overall satisfaction.

Since the breakthrough, 18-year-old Rose Anderson from Stretford in Manchester has received a diagnosis of one of the newly discovered conditions.

Rose has been known to the team at the Manchester Centre for Genomic Medicine at Manchester University NHS Foundation Trust (MFT) for nearly her whole life, although a precise diagnosis for her seizures and developmental delay has proved difficult to find.

On receiving the news from the Manchester research team last year, Rose������Ƶ�s mum Lyn said: ������Ƶ�We felt excited and relieved to finally receive Rose������Ƶ�s diagnosis. Rose is a very happy person, and with any diagnosis, she will always be Rose to us. This has helped us pinpoint what has caused her to be the way she is.������Ƶ�

The study was supported by the MFT-hosted NIHR Manchester BRC, as part of its which aims to improve diagnosis of rare conditions.

Researchers from the NIHR Manchester BRC, MFT, and The University of Manchester (UoM) collaborated with scientists globally to analyse the genetic data of thousands of individuals including those who took part in the a Genomics England initiative to sequence and study the role genes play in health and disease.

Genes are sections of our DNA and contain the instructions for building proteins, which are needed by the body for cell growth and repair.

Parts of our genes that do not make proteins have previously been dismissed as ������Ƶ�dark matter������Ƶ� because they were not understood, or ������Ƶ�junk DNA������Ƶ� because it was thought they were not essential.

Published in Nature Genetics today (date), Manchester researchers have challenged these assumptions, showing that changes in these regions play a crucial role in brain development.

The team found that mutations in regions of the genome that form R-loops (special DNA-RNA structures that can influence genetic activity) are more common than previously thought.

This insight led them to uncover two new neurodevelopmental conditions:

• RNU2-2-related disorder, which is linked to developmental delays, intellectual disability, small head size (microcephaly), autistic traits and seizures.
• RNU5B-1-related disorder, associated with developmental delays, weak muscle tone (hypotonia), larger-than-average head size (macrocephaly), and poor growth.

Neurodevelopmental conditions ������Ƶ� disorders that affect brain development ������Ƶ� impact 2-5% of people worldwide.

For many families, these conditions remain a mystery, as current genetic tests often fail to find a cause.

The two new conditions, along with ReNU syndrome (a condition identified in 2024 which has an impact on learning, behaviour, speech and movement) account for more than 1% of all unsolved developmental cases.

This means the breakthrough could provide a genetic explanation for several thousands of people globally with these conditions.

Rose, who was diagnosed with RNU2-2-related disorder in October 2024, loves music, walking, swimming, visiting cafes and riding a tandem bike. She lives with her mum Lyn, dad Joe and younger sister, Lily.

At Lyn������Ƶ�s 20-week pregnancy scan, it was first suspected that Rose may have a rare genetic condition. Despite undergoing extensive genetic testing at MFT and taking part in research, the team had been previously unable to find a specific cause for Rose������Ƶ�s symptoms.

Lyn said: ������Ƶ�You wonder if it������Ƶ�s just a random thing that has happened or parents sometimes look to themselves for the cause. Rose first started experiencing seizures when she was a baby ������Ƶ� she would become flushed, very vacant and would loll her head to one side. After a bad seizure when she was 2 and a half years old, Rose was diagnosed with epilepsy. She occasionally has seizures now, but these are better managed with medication.

������Ƶ�When Rose went to nursery, younger children began overtaking her with early developmental milestones. Rose is non-verbal and is great at communicating using objects and symbols. She experiences hyperventilation (rapid breathing), can struggle with spatial awareness and needs support with eating and personal care.

������Ƶ�This breakthrough is fantastic, and we hope it will lead to more families receiving a diagnosis now and when early symptoms first appear. This could help improve quality of life for other children and young people and find out what it is that makes them unique.������Ƶ�

Rose and her family are working with the Manchester team to help them better understand RNU2-2 related disorder. Rose has also taken part in more research at MFT since receiving her diagnosis, including donating skin cells to help the team produce brain stem cells for epilepsy research.

Study lead and first author of the paper Dr Adam Jackson, Academic Clinical Fellow at the Manchester Centre for Genomic Medicine at MFT and The University of Manchester and early career researcher in the NIHR Manchester BRC������Ƶ�s Rare Conditions Theme, said: ������Ƶ�By proving that non-protein coding genes play a key role in human health, this study challenges long-held assumptions about ������Ƶ�junk DNA������Ƶ� and brings hope to many families searching for answers.������Ƶ�

Dr Jackson, who is also part of the (MRCC), a virtual centre based at MFT which aims to improve the lives of people with rare conditions, explained: ������Ƶ�Identifying these genetic mutations was a one-year process. They are difficult to understand because they are in the ������Ƶ�dark matter������Ƶ�, so we didn������Ƶ�t know what their effect would be when they don������Ƶ�t produce a protein. It was thought that one of the genes didn������Ƶ�t do anything at all, but our method of looking at R-loop forming regions has highlighted this region to be active.������Ƶ�

15-year-old Noah from the Isle of Wight was diagnosed with RNU5B-1-related disorder by the team at University Hospital Southampton NHS Foundation Trust this year, more than seven years after donating his DNA for the 100,000 Genomes Project.

His mum, Maria Villa Vine, said: ������Ƶ�We were blown away when we received the diagnosis and to find out it was rare. I always knew my boy was special, but this confirmed it! Having a diagnosis can help you understand yourself, so this will support Noah being able to do that.������Ƶ�

Noah������Ƶ�s diagnostic journey began at around 15 months old when his family noticed he wasn������Ƶ�t reaching some milestones that are typically displayed at that age. At four years old, Noah was diagnosed with autistic traits and following a reassessment when he was 12, Noah was diagnosed as autistic.

Following extensive initial genetic investigations by clinicians in Southampton, Noah took part in the 100,000 Genomes Project. This did not find a diagnosis, but his data was entered into the research environment which resulted in the Manchester team������Ƶ�s discovery.

Maria said: ������Ƶ�We took part in the 100,000 Genomes Project because as a family we thought, what������Ƶ�s there to lose? If it can help your child or other children with disabilities in the community, why wouldn������Ƶ�t you? We didn������Ƶ�t expect to hear anything from it until we got the phone call.

������Ƶ�Navigating early years as a parent can be difficult, it������Ƶ�s full of emotion and your brain blocks things out. You can feel self-blame and guilt, wondering if it������Ƶ�s something you did. It can also be a hard time for siblings ������Ƶ� Noah������Ƶ�s sister was seven at the time of his autism diagnosis. It������Ƶ�s important to have a network of professionals around families to support them and put the children at the centre of conversations.������Ƶ�

This study was supported by the , which facilitates research into the epigenomics of rare diseases and is part of the Medical Research Council and NIHR-funded Rare Diseases UK Platform.

Professor Siddharth Banka, senior author of the study who oversaw the research, is a Professor of Genomic Medicine and Rare Diseases at UoM, Consultant Clinical Geneticist at the Manchester Centre for Genomic Medicine at MFT, and Clinical Director of the MRCC.

Discussing the next steps for the research, Professor Banka, who is also the Rare Conditions Co-Theme Lead at the NIHR Manchester BRC and Co-Lead for the EpiGenRare Node, said: ������Ƶ�We now want to understand these conditions better, such as how do their symptoms evolve over time, are there any associated complications and discover potential treatment options. We also need to understand the mechanism of the disease better ������Ƶ� how exactly are these genetic mutations causing neurodevelopmental conditions? With this information, we hope to identify treatments and therapies, and make these available for patients.������Ƶ�

The Manchester-based team������Ƶ�s findings have also had a positive impact on patients and families worldwide.

In Australia, the breakthrough has meant that clinicians there were able to diagnose with RNU2-2-related disorder after a decade-long diagnostic journey.

Gitty������Ƶ�s mum, Miriam, said: ������Ƶ�We felt very relieved when we found out. The diagnosis didn������Ƶ�t change anything because Gitty was 10 years old at this stage and we������Ƶ�ve lived through all these symptoms. But knowing that it won������Ƶ�t affect our other children and can������Ƶ�t be passed down by them was a big relief. Uncertainty can be very unnerving, so having a diagnosis gives us peace of mind.������Ƶ�

Professor Marian Knight, Scientific Director for NIHR Infrastructure, said: ������Ƶ�For parents of children with neurodevelopmental conditions, understanding the cause of symptoms is an essential first step to getting the best help for their child. The experimental medicine championed by our NIHR Biomedical Research Centres which leads to important discoveries like this provides real benefits for real people like Rose. This exciting work has the potential to change the care of patients not only in the UK but around the world."

Dr Sarah Wynn, CEO of Unique, a charity which supports families affected by rare genetic disorders, said: ������Ƶ�This research study which has discovered two new frequent causes of neurodevelopmental conditions is incredibly important and valuable to patients and families, who have often been searching for a long time for the answer to their child������Ƶ�s developmental delays. Receiving a diagnosis like this can be life-changing for families, not only by providing the explanation they have been looking for but enabling them to connect to others and learn more about the condition resulting in improved care and support for their child. We are enormously grateful to research teams such as this, who work tirelessly to discover new gene associations and understand more about rare genetic conditions bringing benefit to people and families all over the world.������Ƶ�

At a ceremony in the historic Whitworth Hall, he was presented with an honorary doctorate by the University������Ƶ�s Chancellor, Nazir Afzal. The award is in honour not only of his sporting success but for his inspirational work away from football, including through his family foundation, the Guardiola Sala Foundation.

Pep said: ������Ƶ�Manchester means so much to me. I have spent nine years here and it has become home. The people, the culture, my incredible football club, my colleagues������Ƶ� it is all so special to me and my family.  When I arrived here in 2016, I did not know how long I would spend here. The way this city embraced me made everything easy. My time here has been beautiful. 

������Ƶ�I know how important the University of Manchester is to our city. It������Ƶ�s the home to a lot of research and it has a history of discovery. So, honestly, to be honoured in this way by such an esteemed institution is an amazing feeling. I want to thank everyone at the University of Manchester for this moment ������Ƶ� and I want to thank everyone at Manchester City for their constant support.������Ƶ�

Professor Duncan Ivison, President and Vice-Chancellor of The University of Manchester, said: ������Ƶ�Pep wasn������Ƶ�t born in Manchester, but like me and so many others, the city has welcomed him and made it feel like home. That welcome and the way Manchester gets under your skin is why so many people feel a deep, lifelong connection with the city.

������Ƶ�Pep is an innovator and a winner who has inspired millions of people through his success as a manager. He has played a huge role in making Manchester a global success story and we are honoured that he has chosen to accept this degree. I hope that this forges another important connection between him, the University of Manchester, and the city.������Ƶ�

Honorary degrees are the highest awards the University can offer. The University recognises remarkable individuals that have made outstanding contributions to society that embody its values, improve the lives of people in local communities or have created significant impact in their field of work and often far beyond.

Widely regarded as one of the successful and innovative managers in the history of the game, Pep followed a trophy laden playing career by being appointed as manager of the Barcelona first team in 2008. He won the La Liga title in three of his four seasons at the Camp Nou and lifted the UEFA Champions League twice.

After Barcelona, he joined Bayern Munich whom he led to the last four of the UEFA Champions League in each of his three seasons, landing the Bundesliga three times and winning the league and cup double twice.

Guardiola joined City in 2016. In his second season he guided the Cityzens to the Premier League title and the Carabao Cup. He picked up four successive Manager of the Month awards and was voted the Premier League Manager of the Season and the LMA Manager of the Year.

He was again voted Premier League Manager of the Season after guiding City to four more trophies in 2018/19 to become the Club������Ƶ�s most successful boss ever with six trophies in three seasons.

City added the Carabao Cup and Community Shield to Pep������Ƶ�s list in 2019/20, but the Catalan won yet more silverware in 2020/21, with another Premier League title and Carabao Cup success. He also became the first City boss to take his side to a Champions League final in May 2021, taking his trophy haul to 10. ������Ƶ�Guardiola������Ƶ�s incredible spell at the Etihad saw him claim a fourth Premier League title in five years in 2021/22 and a fifth in 2022/23.

And to top off another history-defining season under Pep������Ƶ�s tenure, a fifth league win and City������Ƶ�s FA Cup final win followed by victory in the Champions League final saw the club named Treble winners in 2022/2023.

On the final day of the 2023/24 season, City became the first club to win the Premier League in four successive seasons, confirming the title on the final day.

Pep������Ƶ�s leadership has not only elevated the club������Ƶ�s success but is a model for performance excellence and continuous improvement that has inspired leaders outside of football. Alongside this, the University wanted to recognise his contributions to Manchester������Ƶ�s cultural and community life, and unwavering commitment to social responsibility and justice, through his family foundation - the Guardiola Sala Foundation. 

●&�Բ�����;&�Բ�����;&�Բ�����;&�Բ�����;&�Բ�����; Led by The University of Cambridge and The University of Manchester, and supported by the two Mayoral Combined Authorities, City Councils, alongside businesses and investors

A groundbreaking partnership between The University of Manchester and The University of Cambridge has been awarded ������Ƶ4.8 million by Research England to accelerate inclusive growth and innovation collaboration. As the UK������Ƶ�s first cross-UK innovation partnership, it will pioneer a new model of place-to-place collaboration and help drive economic growth for the UK- setting an example for other cities to follow. With further investment from the two universities, the total funding for the partnership will be ������Ƶ6m.

The partnership will be led by Unit M and Innovate Cambridge - the universities������Ƶ� respective innovation capabilities - with support from the two Mayoral Combined Authorities, City Councils, businesses and investors. It is a prime example of how a university-led, cross-UK innovation collaboration can enhance the UK's global competitiveness and foster innovation-driven growth.

This initiative responds directly to the UK government������Ƶ�s imperative for universities to support the delivery of the national Industrial Strategy and make a stronger contribution to economic growth.

Professor Duncan Ivison, President and Vice Chancellor of The University of Manchester, commented: "Our partnership with Cambridge marks a new model of collaboration between UK universities. It brings together the distinctive strengths of each of our universities and cities, connecting two of the great innovation ecosystems to scale up what we can achieve. This new approach to innovation accelerates the time between discovery and impact, getting ideas into the real economy and our communities even more quickly to drive inclusive growth.������Ƶ�

Professor Lou Cordwell, Chief Executive of Unit M, said: ������Ƶ�Universities are increasingly taking a lead in convening and catalysing their innovation ecosystems. By bringing together investors, businesses, entrepreneurs, academics, and public sector agencies, this partnership will create new opportunities and stimulate investment into the innovation economy. We are proud at Unit M to be part of such a pioneering partnership, and look forward to continuing to work with Cambridge.������Ƶ�

Professor Deborah Prentice, University of Cambridge Vice-Chancellor, commented: ������Ƶ�This pioneering initiative brings together the combined strengths of Cambridge and Manchester to create something that is truly ground-breaking. By connecting our cities, we������Ƶ�re helping to build a more collaborative and dynamic environment in which innovative research can connect with industry, venture capital and entrepreneurs to drive economic growth and deliver real benefits for people and places across the UK.������Ƶ�

Science Minister and Oxford-Cambridge Growth Champion, Lord Vallance, said: ������Ƶ�This pioneering partnership is proof that our ambitions for the Oxford-Cambridge Corridor can and will fire up economic growth across the length and breadth of the UK, which is critical to our Plan for Change.

������Ƶ�Cambridgeshire and Greater Manchester are forging a path I hope others will follow. Science is always stronger when we work together, and stronger research ties between the UK������Ƶ�s great regions will only lead to more investment, more opportunities, and more breakthroughs, from health to clean energy and beyond.������Ƶ�

Jessica Corner, Executive Chair of Research England, commented: ������Ƶ�This investment underscores our commitment to fostering innovation and collaboration across England. By connecting the vibrant ecosystems of Cambridge and Manchester, we aim to drive significant economic growth and create a model for place-based innovation that can be replicated nationwide."

At the core of the partnership is the exchange of complementary innovation assets to ensure real-world impact. Both cities already have strong R&D capabilities and strengths in leading-edge sectors such as AI, life sciences, and advanced materials. Cambridge has deep investor networks but experiences growth constraints due to its small scale, higher costs, and lack of development land. Manchester provides that scale, affordability for start-ups and scale-ups, and a large talent pool - but has a less mature support ecosystem.

The Research England funding will be used in three key areas: ecosystem activation and integration; growing investment; and testing and learning.

●&�Բ�����;&�Բ�����;&�Բ�����;&�Բ�����;&�Բ�����; Ecosystem activation and integration: It will strengthen relations within and between the innovation ecosystems of the two cities, to create a vibrant and ambitious cross-city innovation network. This aims to create progressive new approach inclusive growth.

●&�Բ�����;&�Բ�����;&�Բ�����;&�Բ�����;&�Բ�����; Growing investment: It will harness the combined strengths of both universities and partner cities to support start-ups and scale-ups to secure funding and grow, attract innovation-intensive FDI to the UK, and stimulate investment into R&D.

●&�Բ�����;&�Բ�����;&�Բ�����;&�Բ�����;&�Բ�����; Testing and learning: It will pilot new approaches and share best practice for delivering ecosystem collaboration and inclusive growth. This will allow other cities, the wider higher education sector community, and local and national governments in the UK and internationally to learn from the partnership.

Recognised as both a City of Literature and a City of Lifelong Learning, Manchester joins a select group of global cities acknowledged for their commitment to education, creativity and cultural development. 

The University of Manchester, Manchester Metropolitan University, and Manchester City Council came together yesterday to celebrate Manchester������Ƶ�s dual status as a UNESCO City of Lifelong Learning and Literature. 

The celebration was held at Manchester Metropolitan University, and The University of Manchester������Ƶ�s President and Vice-Chancellor Duncan Ivison delivered the event������Ƶ�s closing remarks. 

The UNESCO status of City of Lifelong Learning is an important accolade for The University of Manchester, as lifelong learning is one of the University������Ƶ�s key focuses.  

Lifelong learning provides the opportunity for access to a University of Manchester education without the commitment of full-time on campus study, creating a more flexible and inclusive learning environment. 

Outside of the classroom, lifelong learning also provides support for learner������Ƶ�s personal and professional development, aligning with industry and employer needs by driving economic, social and cultural progress. 

The University is continuously working with students, alumni, businesses and strategic industry partners to make The University a Learning Partner for Life.   

Professor Ang Davies, Academic Lead for Lifelong Learning at The University of Manchester, said: ������Ƶ�We are extremely proud to join the UNESCO family of Learning Cities and have already made many connections in the UK and beyond.������Ƶ�

Mags Bradbury, Head of Social Responsibility & Civic Engagement at The University of Manchester, said: ������Ƶ�We are proud to be part of this city-wide partnership, working with civic partners, supporting the ambitions of our city. It������Ƶ�s great that we can share what we are doing locally on lifelong learning through UNESCO, delivering in Manchester our commitment to the global UN Sustainable Development Goals.������Ƶ�  

The UNESCO City of Lifelong Learning designation was given to Manchester last February. In a short period of time, the partnership has launched over 90 projects, delivered events reaching 14,000 learners and over 2,000 learning and skills specialists have attended professional development events. Three films, launched this week, showcase the impact of the designation on learners and providers.   

The event also showcased the projects from artists funded by the British Council������Ƶ�s International Collaboration Grant, who have been collaborating between Manchester and Nanjing - one of few other cities globally to have this prestigious dual designation. Yesterday������Ƶ�s event marked the culmination of a 9-month artistic exchange exploring the natural world through literature.  

Also showcased at the event was an exhibition of artwork and writing by young students, developed through a school engagement programme involving Year 3-6 pupils from Manchester and Nanjing schools. The work created by the artist exchange and schools programme will be open to the public as part of Festival of Libraries at Manchester Central Library from 3 - 17 June 2025. 

Ivan Wadeson, Executive Director of Manchester City of Literature, says: ������Ƶ�Huge thanks to Arts Council England and the British Council International Collaboration Grants for their support to make this happen, alongside the regular funders of Manchester City of Literature: Manchester City Council, The University of Manchester and Manchester Metropolitan University.������Ƶ�

Jill Griffiths, Head of the School of Digital Arts and Academic Lead for Lifelong Learning at Manchester Metropolitan University, said: ������Ƶ�It������Ƶ�s a privilege to host the event at Manchester Metropolitan University in celebration of the UNESCO City of Lifelong Learning and City of Literature designations. 

������Ƶ�Working in partnership with Manchester City Council and The University of Manchester to attain these designations is a reflection of the collaborative ethos of the city and Manchester Met, and this event, which also took place during the Festival of Libraries, was a vibrant celebration showcasing the breadth and depth of our creative and cultural offering alongside our commitment to making lifelong learning a reality for everybody within Manchester.������Ƶ�

To find out more about the artist exchange, exhibition and project please visit:  

To find out more about the British Council International Collaboration Grants please visit:  

Join us on Saturday 14 June, 11am - 4.30pm for a day of creativity, discovery and play. Our free community festival offers something for everyone with inspiring talks and performances, hands-on science experiments, art and crafts workshops, heritage tours and more.

One of the festival������Ƶ�s standout features is the Bee Curious programme, featuring thought-provoking talks and performances for all ages. Highlights include: exploring the science and art behind how our brains respond to everyday environments, people we see, and places we visit with Dr Sarah Fox and Dr Henry McPherson;  taking an interstellar journey to find out about other worlds with Dr Eamonn Kerins as the Jodrell Bank Alien; and exploring links between creativity and wellbeing to find joy in the everyday with Manchester-based poet, Rebecca Hurst. 

Step back in time with Grant Collier and explore the roots of our revolutionary institution on a guided historic walking campus tour. Uncover the rich tapestry of history that makes our campus unlike any other. As the nation������Ƶ�s first ������Ƶ�civic������Ƶ� university, our unique identity has pushed us to global prominence and this tour offers a fantastic opportunity to learn about pioneering individuals and groundbreaking discoveries.

Try your hand at street art with local art collective Grit Studios, presenting The Art of Research, a vibrant showcase of artwork inspired by research at the University. There������Ƶ�ll be a series of free drop-in workshops throughout Saturday, so release your inner artist and get creative with sprays and stencils.

Come plant with us! Pop along to our University community allotment a partnership between the University and Ardwick Climate Action and get hands-on with planting and sustainability.  Then visit the co-curated, community exhibition Blue Skies at Manchester Museum, which asks a critical question: ������Ƶ�You wouldn������Ƶ�t drink visibly dirty water, so why would you breathe invisibly dirty air?������Ƶ�

Together we������Ƶ�ll explore what makes for a greener, healthier and fairer world for everyone. Take part in over 80 interactive stalls. Uncover the mysteries of the human body as we take a closer look at our hands, hearts and minds. Interact with robot companions, step into a world of virtual reality and explore the wonder of space. Meet the makers of marvellous materials. Enjoy wellbeing and craft making activities, learn the art of calligraphy and don on a University graduation gown! There������Ƶ�s plenty to discover and do ������Ƶ� with activities on offer for all ages. 

Be amazed by the power and joy of chemistry in our visually exciting Flash Bang Show with Dr Frank Mair. Expect fantastic colour changes, flashes and the occasional bang - get ready to hold on to your hats!

Our Universally Manchester Festival is taking place on our Oxford Road campus and is free and open to everyone.

Find out more about our family-friendly activities on the .

This milestone reflects The University������Ƶ�s strategic vision to expand access to education and foster inclusive, innovative learning environments. By becoming a member of EUCEN, The University of Manchester aims to: 

• Enhance collaborative opportunities: Partner with a diverse network of European institutions to exchange knowledge and develop joint continuing education initiatives. 
• Influence educational policy: Contribute to shaping European policies that support lifelong learning and address the evolving needs of learners. 
• Promote innovation in learning: Embrace and share best practices and technologies that enable flexible, accessible learning pathways. 

Through active participation in EUCEN������Ƶ�s programmes and initiatives, The University seeks to help drive advancements in lifelong learning and implement responsive educational programmes that meet the needs of diverse populations. 

Founded in 1991, EUCEN is a leading association dedicated to university lifelong learning - the provision of educational opportunities, services, and research by higher education institutions to support personal and professional development throughout life. University lifelong learning also plays a vital role in driving social, cultural, and economic progress in communities and regions. 

Pascal Paschoud, President of EUCEN said: ������Ƶ�EUCEN is truly delighted to welcome The University of Manchester to our network. As a leading UK institution with a strong commitment to lifelong learning, their dedication to making a real impact aligns perfectly with our mission. We look forward to their active involvement and collaboration. Together, we can strengthen the role of university lifelong learning in building innovative, sustainable and inclusive economies and societies.������Ƶ�  

EUCEN currently includes 163 member institutions across 36 countries. Its platform supports knowledge sharing, the development of innovative educational strategies, and policy advocacy in lifelong learning. 

Also inducted at the 2025 conference was Imperial College London, making The University of Manchester one of only four UK institutions in the network������Ƶ�alongside the Universities of Oxford, Sunderland, and Imperial. 

While pollution levels from road traffic have fallen significantly thanks to policies like the Ultra Low Emission Zone (ULEZ), new air pollution data from scientists at The University of Manchester, in collaboration with the UK Centre for Ecology & Hydrology (UKCEH), University of York, Zhejiang University and National Centre for Atmospheric Science, reveal emissions from non-road mobile machinery, such as generators and heavy-duty construction equipment, can exceed those from vehicles, particularly in areas where there is a lot of building activity.

Black carbon is soot from combustion and is a component of particulate matter (PM2.5). These are very fine particles that can enter the lungs and bloodstream and are known to damage human health. 

The team collected the pollution measurements from the top of the BT Tower in central London over summer and winter, using a technique called eddy covariance to track how much black carbon is released into the air and where it comes from.

The findings revealed that while pollution levels were significantly lower than cities like Beijing and Delhi, who have monitored pollution using the same method, they are not low enough to meet the . They suggest similar regulatory attention to road traffic is now needed for the construction sector. 

The study, published in the journal is the first of its kind in Europe.

At 190 metres tall, the BT Tower observatory has a specialised gas inlet system installed on the tower������Ƶ�s roof, which draws air into a laboratory on the 35th floor, allowing researchers to analyse pollution as it rises from streets, buildings, construction sites and nearby parks below.

The ������Ƶ�eddy covariance������Ƶ� method works by measuring the turbulent motion of air, also known as eddies, and the concentration of airborne substances like black carbon within those eddies.

The scientists also conducted a detailed spatial footprint analysis to pinpoint emission hotspots that were directly linked to active construction sites near the BT Tower.

The new findings suggest that further progress in improving London������Ƶ�s air quality will require stricter regulation of construction machinery, especially in rapidly developing areas.

added: ������Ƶ�We compared observed emissions with emission standards for construction equipment and found that even with compliance, black carbon output from generators, machinery and construction vehicles remains significant. Our work highlights how measurement techniques like eddy covariance can fill critical gaps in our understanding of urban pollution and support evidence-based strategies to protect public health and the environment.������Ƶ�

This research was published in the journal Environmental Sciences: Atmospheres

Full title: Quantifying black carbon emissions from traffic and construction in central London using eddy covariance

DOI:

Led by researchers at The University of Manchester, the study reveals that invisible, odourless gases like helium and argon are slowly seeping hundreds of kilometres up through Earth������Ƶ�s crust, reaching underground water supplies thousands of meters beneath our feet.

For decades, scientists have believed that the vast majority of Earth������Ƶ�s internal gases are either pushed deep underground through tectonic activity, or escape back to the surface through volcanic eruptions.

The new research, published in the journal , challenges this understanding  and the findings could give scientists a better idea of the geological and chemical processes that take place deep inside the Earth.

������Ƶ�Think of it like a having small puncture in your car tyre,������Ƶ� said lead author Dr Rebecca Tyne, Dame Kathleen Ollerenshaw Fellow at The University of Manchester.

������Ƶ�We������Ƶ�ve discovered a steady trickle of gases coming from deep within Earth, even though there������Ƶ�s no obvious volcanic activity on the surface.

������Ƶ�This passive degassing of the mantle may be an important, yet previously unrecognised process and these findings will help our understanding of how our planet������Ƶ�s interior works  and how much gas is escaping into the atmosphere over time. It could even play an important role in the geologic carbon cycle������Ƶ�

The researchers analysed groundwater from 17 wells in the Palouse Basin Aquifer in the United States - a key source of drinking water in a region considered to be geologically stable.

Using advanced measurement techniques, they measured for multiple types of helium and argon and found signatures to suggest these gases had travelled up from the Earth������Ƶ�s mantle ������Ƶ� the hot, dense layer between the outer crust and the core. Importantly, the helium and argon gases detected are inert, meaning they do not react chemically or affect water quality.

Co-author Dr Mike Broadley , NERC Independent Research Fellow at The University of Manchester, said: ������Ƶ�We found evidence of mantle-derived gasses in 13 out of the 17 wells.  These gases ������Ƶ� especially helium-3 and argon-40 ������Ƶ� do not form in the atmosphere or in shallow rocks, they come from a layer of the mantle called the sub-continental lithospheric mantle, many kilometres deep in the Earth.������Ƶ�

The highest amount of gas was found in the oldest and deepest groundwater samples - some over 20,000 years old - indicating the gases have been moving slowly but steadily over a long period of time.

The researchers also found a strong correlation between the samples, suggesting they are travelling up together from the same deep source.

Their findings suggest that this kind of low-level, non-volcanic degassing may be more common ������Ƶ� and more important ������Ƶ� than previously thought. The team are now planning to investigate whether this is a globally consistent phenomenon by investigating groundwaters worldwide.

The research was carried out in collaboration with Woods Hole Oceanographic Institution (USA),  Université de Lorraine (France), University of Ottawa (Canada) and the University of Idaho (USA).

Journal: Nature Geoscience

Full title: Passive degassing of lithospheric volatiles recorded in shallow young groundwater

DOI: 10.1038/s41561-025-01702-7

Link:

The breakthrough, , the U.S. Department of Energy������Ƶ�s Fermi National Accelerator Laboratory, brings researchers one step closer to discovering forces or particles beyond the Standard Model of physics.

This result represents the most precise measurement ever made at a particle accelerator anywhere in the world, and could help unlock the secrets of the universe.

What is the Muon g-2 Experiment?

The Muon g-2 experiment investigates the subtle ������Ƶ�wobble������Ƶ� in the motion of muons, particles similar to electrons but with 200 times more mass, as they move through a magnetic field.

This wobble, known as the muon������Ƶ�s ������Ƶ�anomalous magnetic moment������Ƶ�, or g-2, provides one of the most sensitive and precise tests of the Standard Model of particle physics, the theory that explains how fundamental particles and forces interact.

Landmark results

This announcement reveals the experiment������Ƶ�s third and final measurement, which confirms earlier results, but with a much better precision of 127 parts-per-billion, surpassing the original experimental design goal of 140 parts-per-billion.

These results now stand as the world������Ƶ�s most accurate measurement of the muon magnetic anomaly.

Representing more than a decade of work, this milestone is expected to stand as the definitive benchmark for testing the Standard Model for years to come.

Critical UK contribution

Scientists from the Universities of Manchester, Lancaster, Liverpool, and University College London were central to the experiment, which brought together 176 researchers from 34 institutions across seven countries.

The UK-built straw tracking detectors were essential in tracing the motion of the muon beam, a critical part of the analysis that enabled this unprecedented level of precision.

The University of Manchester was responsible for mapping the vertical oscillations in the beam motion using the detectors and in the theory prediction for the measured value.

Professor Mark Lancaster, Principle Investigator of the UK groups from The University of Manchester, said: ������Ƶ�This is the most precise measurement ever made at a particle accelerator and the culmination of over a decade������Ƶ�s work. The motion of the muon beam was exquisitely traced by the UK-built straw tracking detectors and was a key part of the analysis. That we now have a measurement to a precision of 0.1 parts per million and a theoretical prediction, to 0.5 parts per million, is a remarkable achievement from the work of hundreds of people.������Ƶ�

STFC������Ƶ�s Professor Sinead Farrington, Director of Particle Physics, added: ������Ƶ�What������Ƶ�s really fascinating about this result is the way it has illustrated the interplay between theoretical predictions and experimental results - each can lead the other, and make demands on the precision of the other.  

������Ƶ�The UK has played critical roles of which we can be proud, both in leadership and in developing the straw tracking detectors, in this highly international collaboration.������Ƶ�

Read the at the Fermilab website.

To mark its 60^th anniversary, Alliance Manchester Business School (AMBS) is bringing back its Festival of Business, expanding on the success of last year������Ƶ�s inaugural event.

Taking place across four days from the 16^th to 19^th June, the festival will bring together industry leaders, policymakers and academic experts to discuss the role businesses have to play in helping society respond to the pressing challenges and opportunities of our time.

Headlining the festival will be the ������Ƶ�Innovate 2050������Ƶ� day on Thursday 16^th featuring panel discussions exploring the future of media, finance and digitalisation.

Alongside an impressive line-up of AMBS������Ƶ�s leading thinkers, the day will see the likes of Siobhan Morgan, head of development at the producers of hit TV show, Adolescence, Warp Films; Kerris Bright, chief customer officer at the BBC, and Jess McCreadie, investment director at Northern Gritstone, coming together to discuss how their industries are innovating to respond to the world������Ƶ�s biggest challenges including the climate crisis and the emergence of new technologies like AI.

Alongside this, other events will be running throughout the festival focussing on themes including professional development, the future of the Third Sector and empowering entrepreneurs. The Festival of Business comes as AMBS celebrates six decades of empowering leaders, thinkers and visionaries across the globe to deliver transformative and innovative change.

Ken McPhail, Head of Alliance Manchester Business School, said: "We are currently living through a critical period as we face challenges including economic growth and regional disparities, global geopolitical upheaval and climate change. Rising to these challenges won������Ƶ�t be possible without business playing key leadership role in finding solutions and capitalising on opportunities."

Further details about the Festival of Business, along with information on how to get tickets to the events running throughout it, can be found .

Sarah joins the University from the Department for Transport where she has been Chief Scientific Adviser since 2021, seconded from the University of Nottingham. At the DfT she leads on many of the engineering and science challenges in transport, including decarbonisation, applications of artificial intelligence and cross-modal safety.

She is an international expert in the field of human factors and its application to engineering problems. Human factors is a scientific discipline which uses an understanding of human capabilities and limitations to design systems to support human performance, wellbeing and safety.

Sarah has previously held the roles the Pro-Vice Chancellor for Equality, Diversity and Inclusion and People (2018-2021) and Associate Pro-Vice Chancellor for Research and Knowledge Exchange (Engineering) (2015-2018) at the University of Nottingham.

She has recently been appointed to the role of Deputy Chair of Research Excellence Framework (REF) 2029 Unit of Assessment Panel 12 (Engineering), was previously a member of EPSRC Council and Advance HE Athena Swan Governance Board and is currently the CSA member of ESRC Council.

She was President of the Chartered Institute of Ergonomics and Human Factors 2015-2016 and her academic research, funded by industry and UKRI, has considered how complex systems bring people and technology together in the domains of transport, healthcare and manufacturing.

Sarah and her husband Craig are parents to two grown up children, and in her spare time, Sarah applies her passion for human-centred complex systems design to the hobbies of cooking and gardening.

Professor Duncan Ivison, President and Vice-Chancellor, said: ������Ƶ�As we develop our 2035 strategy, having Sarah join our leadership team is going to be a great asset to the University. The Faculty of Science and Engineering is critical to our ambition to be one of the world������Ƶ�s great universities by 2035, through research impact, innovation and modern, flexible teaching. I������Ƶ�m very much looking forward to working with her.������Ƶ�

Sarah will join the Faculty in mid-September. Professor Peter Green will be interim Vice-President and Dean in the intervening period.

In September 2023, scientists observed a bizarre series of global seismic signals, which appeared every 90 seconds over nine days ������Ƶ� and then repeated a month later.

Almost a year later, two scientific studies proposed that the cause of these seismic anomalies were two mega tsunamis which were triggered in a remote East Greenland fjord by two major landslides which occurred due to warming of an unnamed glacier. The waves were thought to have become trapped in the fjord system, forming standing waves (or seiches) that undulated back and forth, causing the mystery signals.

Until now, there have been no observations of these seiches to confirm this theory.

Now, using a brand-new type of satellite altimetry, a team of researchers have confirmed the theory and provided the first observations of these waves whose behaviour is entirely unprecedented.

The new research is published today in the journal .

, Lecturer in Fluid Mechanics at The University of Manchester, who carried out the research in Oxford, said: ������Ƶ�It's impressive to see that machine learning plays an important role in identifying these trapped waves. This research demonstrates how advancements in technology are enabling new observations and datasets, and also importantly, changing our approach to extracting scientific insights from large-scale data.������Ƶ�

Using data from the Surface Water and Ocean Topography (SWOT) satellite, the research team were able to capture the wave activity for the first time. SWOT launched in December 2022 to map the height of water across 90% of Earth������Ƶ�s surface. It is equipped with the cutting-edge Ka-band Radar Interferometer (KaRIn) instrument, which uses two antennas to measure ocean and surface water levels across a swath 30 miles wide.

The researchers then made elevation maps of the Greenland Fjord at various time points following the two tsunamis. These showed clear, cross-channel slopes with height differences of up to two metres. Crucially, the slopes in these maps occurred in opposite directions, showing that water moved backwards and forwards across the channel.

To validate their findings, the researchers linked these observations to small movements in the Earth������Ƶ�s crust recorded thousands of kilometres away, allowing them to reconstruct the characteristics of the wave, even for periods which the satellite did not observe. They also reconstructed weather and tidal conditions to rule out alternative explanations such as wind or tides.

Lead author (DPhil student, Department of Engineering Science, University of Oxford) said: ������Ƶ�Climate change is giving rise to new, unseen extremes. These extremes are changing the fastest in remote areas, such as the Arctic, where our ability to measure them using physical sensors is limited. This study shows how we can leverage the next generation of satellite earth observation technologies to study these processes.

������Ƶ�SWOT is a game changer for studying oceanic processes in regions, such as fjords, which previous satellites struggled to see into.������Ƶ�

Co-author (Department of Engineering Science, University of Oxford) said: ������Ƶ�This study is an example of how the next generation of satellite data can resolve phenomena that has remained a mystery in the past. We will be able to get new insights into ocean extremes such as tsunamis, storm surges, and freak waves. However, to get the most out of these data we will need to innovate and use both machine learning and our knowledge of ocean physics to interpret our new results.������Ƶ�

This research was published in the journal

Full title: Observations of the seiche that shook the world

DOI: 10.1038/s41467-025-59851-7

The University of Manchester now sits behind Oxford, Imperial, Cambridge and University College London, a position that reflects the University������Ƶ�s successful growth in research partnerships and business collaborations, driven by its Business Engagement and Knowledge Exchange team.

From the Covid-19 pandemic in 2020/21 through to the latest 2023/24 dataset, The University of Manchester saw 47% growth in industry funding to ������Ƶ30.1million, almost doubling on the sector average of 24%. In the last year, The University of Manchester������Ƶ�s industry income grew by an impressive 19% against the backdrop of a 0.2% contraction across the sector.  

The annual Higher Education Statistics Agency (HESA) sets out the income and expenditure of all higher education providers across the sector, providing a detailed national picture of university finances. The survey provides information on the total industry funding received, broken down by UK, EU, and non-EU industry funding.

The University������Ƶ�s Business Engagement and Knowledge Exchange team is also celebrating the results of the latest Higher Education Business Community and Interaction (HE-BCI) . The survey captures knowledge exchange activity more broadly and provides information on collaborative research and contract research with both SMEs and larger organisations. 

In the latest survey, Manchester ranked second for contract research with SMEs. It also took fourth place for collaborative research with larger organisations and seventh for total contract research.

Professor Richard Jones, Vice-President for Regional Innovation and Civic Engagement said: ������Ƶ�Our partnerships with industry represent one crucial route by which the outcomes of our research support much-needed productivity growth in the economy, both nationally and in our region. 

������Ƶ�It������Ƶ�s great to see that so many companies ������Ƶ� including a record number of the SMEs that are so important for Greater Manchester������Ƶ�s economy ������Ƶ� want to work with our outstanding researchers to create a more innovative and prosperous future.������Ƶ�

Dr Louise Bates, Director of Business Engagement and Knowledge Exchange, said: ������Ƶ�I am thrilled to see the results of the HESA and HE-BCI reports which demonstrate the strides we have made at the University and, in my team, to grow the size and breadth of our industry research portfolio. These collaborations not only provide opportunities to drive business innovation, they also allow us to deliver impact through our research by addressing real world challenges and meeting business need.������Ƶ�

Through partnerships, The University of Manchester is fuelling innovation and growth in the North West and beyond, utilising academic expertise to deliver high quality consultancy, collaborative research and knowledge exchange activities.

Professor Duncan Ivison, President and Vice-Chancellor at The University of Manchester, said: ������Ƶ�Our University is a powerhouse of research and it������Ƶ�s fantastic to see the strength of our research partnerships recognised in the latest HESA data. This reflects the outstanding work of our Business Engagement and Knowledge Exchange team, and speaks to our broader mission - using knowledge to drive innovation, support business, and tackle pressing challenges here in the North West and beyond.������Ƶ�

The University������Ƶ�s Business Engagement and Knowlege Exchange team are proud to facilitate partnerships with some of the world's largest organisations along with regional and national SMEs. The team support collaborations which tackle global challenges through interdisciplinary research, as well as supporting industry to develop new products, processes and services.

The charity Versus Arthritis has awarded ������Ƶ3m to bring world-leading experts from five UK universities together to accelerate clinical epidemiology research, which will help answer pressing questions from those living with arthritis. 

Professor Kimme Hyrich, Director of The University of Manchester Centre for Musculoskeletal Research will co-lead the consortium with Professor Christian Mallen, Executive Dean and Professor of General Practice and Public Health at Keele University. 

Professor Hyrich, a leading clinical epidemiologist and consultant rheumatologist, highlights the advantages of team science in epidemiological research: ������Ƶ�This award represents an exciting step-change in the way musculoskeletal epidemiology research is conducted in the UK, breaking down traditional research siloes and uniting minds, data and expertise to generate the evidence needed to support people living with arthritis and other painful musculoskeletal conditions."  

The new research consortium is part of the charity������Ƶ�s drive to harness ������Ƶ�team science������Ƶ� to better understand the causes and risk factors for arthritis and improve treatment options. Epidemiology ������Ƶ� the study of how diseases occur in different people and why - is critical to designing better and targeted interventions using data.   

The consortium, made up of experts from the Universities of Manchester, Keele, Oxford, Nottingham and Aberdeen, aims to close five gaps in our understanding of the debilitating disease and related conditions. They will consider menopause in relation to musculoskeletal health, inequalities in access to care, risks of long-term pain medications and determine the optimum levels of monitoring for those receiving immune drugs.  The researchers will also aim to identify those at higher risk of chronic pain sooner, given painful musculoskeletal conditions often begin in childhood. This holds the potential to explore ways to prevent or reduce persistent pain.  

Lucy Donaldson, Director of Research at Versus Arthritis, said: ������Ƶ�The Versus Arthritis Research Consortium: Musculoskeletal Epidemiology - Better lives, Safer journey is a major step forward in tackling the everyday realities faced by people living with arthritis and other painful musculoskeletal conditions.  

������Ƶ�This consortium will bring together leading researchers, clinicians, and people with lived experience from across the UK in a team science approach. Their aim - to find real, practical solutions to the problems faced by people with arthritis.������Ƶ�  

The consortium will employ cutting edge analysis techniques on existing datasets to fill the identified gaps in our knowledge of arthritis and MSK conditions. Its findings will help to arm those living with arthritis to have informed conversations with clinicians about their care. It will also seek to improve clinical practice and policy around diagnosis, prevention and treatment.  

Professor Mallen, Keele University, said: "The new Versus Arthritis Research Consortium is an exciting new programme that will have a major impact on the lives of people living with painful conditions by uniting world-leading clinicians, academics, patients and policy makers.  

������Ƶ�It is a privilege to co-lead the consortium with Professor Hyrich and having strong representation from Keele University highlights the importance of primary care in improving outcomes for people living with arthritis and chronic musculoskeletal pain." 

The results will be shared through a broad range of partners including government, the NHS, clinicians and patient networks.  

More than 20 million people, of all ages, in the UK have problems with their joints, bones and muscles, which cause pain and impact all aspects of life including work and school.  

The Versus Arthritis Research Consortium: Musculoskeletal Epidemiology - Better lives, Safer journey is the first of six consortia to be announced by Versus Arthritis which is awarding ������Ƶ18 million of funding to this initiative over the next three years. 

The annual prize is one of the most prestigious museum awards in the world and Manchester Museum, part of The University of Manchester, is the first university museum to receive it, earning recognition for the way it balances globally-significant academic research with community engagement and social responsibility. 

Judges praised how Manchester Museum has ������Ƶ�reimagined its mission, acknowledging and addressing its complex history by redefining the role of its collections and public programmes.������Ƶ� Its approach to co-curation was cited as part of this, working with local and diasporic communities to bring new perspectives to collections and challenge traditional narratives. The South Asia Gallery, a British Museum partnership, is a key element of this, co-curated with 30 inspiring community members from across the South Asian diaspora, who were able to tell their own stories in their own words and on their own terms. 

Manchester Museum was also praised for ������Ƶ�thoughtful, informed, and impactful community engagement, creating a truly inclusive space where all individuals, regardless of identity or background, can see themselves reflected and represented.������Ƶ� The Manchester Museum Celebrates programme of events, created in collaboration with charities, faith organisations and community activists, aims to build understanding between cultures, bringing people together to celebrate culturally-significant events such as Lunar New Year, Vaisakhi, Africa Day and Iftar. 

Meanwhile, the Museum������Ƶ�s Top Floor has been transformed into a social and environmental justice hub, creating a space for collaboration with charities and non-profit organisations helping Greater Manchester������Ƶ�s communities take action on the issues they care about. It acts as the headquarters for Pinc College, a specialist creative education college for neurodivergent young people, aged 16 to 24. 

These initiatives are part of a wider, values-led transformation, underpinned by a ������Ƶ15 million redevelopment, which was completed in February 2023. 

Operated by the European Museum Forum (EMF), EMYA recognises new or redeveloped museums that showcase the best in excellence and innovation in their field. It aims to recognise museums that promote inter-cultural dialogue and community participation, demonstrate a commitment to sustainability, and show creative and imaginative approaches to the production of knowledge. 

Previous winners include Sámi Museum Siida in Northern Lapland, Finland, Naturalis Biodiversity Center in Leiden, Netherlands, Rijksmuseum Amsterdam, The Design Museum in London, and Guggenheim Museum Bilbao. 

Manchester Museum won the main prize in the face of competition from 41 other shortlisted museums from across the continent. The award was presented on Saturday 25 May, during the EMYA2025 Annual Conference and Awards Ceremony at the Sybir Memorial Museum in Białistok, Poland on 25 May 2025. 

Senior author Dr Ben Brown is a practicing GP and co-founder of Patchs, as well as a researcher at The University of Manchester. He said: ������Ƶ�AI has the potential to reduce the heavier workload which is sometimes associated with eVisits in general practice.

������Ƶ�Despite the potential, AI tools are not yet routinely used in primary care. This study is the first to ask if this use of AI would be acceptable to staff and patients.������Ƶ�

Co-author Professor Niels Peek from The Healthcare Improvement Studies Institute, University of Cambridge said: ������Ƶ�This work aligns with the government������Ƶ�s strategy to address the high workload that the NHS is facing with technology.

������Ƶ�The study demonstrates that there exist opportunities to streamline NHS services with AI in a way that is meaningful for, and would be welcomed by, patients and staff.������Ƶ�